Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Vaccine. 2011 Jul 1;29 Suppl 1:A37-9. doi: 10.1016/j.vaccine.2011.04.125.
Adjuvants are increasingly used by the vaccine research and development community, particularly for their ability to enhance immune responses and for their dose-sparing properties. However, they are not readily available to the majority of public sector vaccine research groups, and even those with access to suitable adjuvants may still fail in the development of their vaccines because of lack of knowledge on how to correctly formulate the adjuvants. This shortcoming led the World Health Organization to advocate for the establishment of the Vaccine Formulation Laboratory at the University of Lausanne, Switzerland. The primary mission of the laboratory is to transfer adjuvants and formulation technology free of intellectual property rights to academic institutions, small biotechnology companies and developing countries vaccine manufacturers. In this context, the transfer of an oil-in-water emulsion to Bio Farma, an Indonesian vaccine manufacturer, was initiated to increase domestic pandemic influenza vaccine production capacity as part of the national pandemic influenza preparedness plan.
佐剂越来越多地被疫苗研发界所使用，这主要是因为它们具有增强免疫反应的能力和节省剂量的特性。然而，它们并不容易被大多数公共部门疫苗研究小组获得，即使那些有合适佐剂的小组也可能因为缺乏正确配制佐剂的知识而在疫苗开发中失败。这一缺陷促使世界卫生组织倡导在瑞士洛桑大学建立疫苗配方实验室。该实验室的主要任务是将无知识产权的佐剂和配方技术转让给学术机构、小型生物技术公司和发展中国家的疫苗制造商。在这种情况下，启动了向印度尼西亚疫苗制造商 Bio Farma 转让水包油乳液，以增加国内大流行性流感疫苗的生产能力，作为国家大流行性流感防备计划的一部分。
