Jiang Qingyun, Li Xinlei, Yin Chengping
Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006, China.
MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Materials (Basel). 2021 May 5;14(9):2407. doi: 10.3390/ma14092407.
Photothermal therapy based on nanoparticles is a promising method for cancer treatment. However, there are still many limits in practical application. During photothermal therapy, improving therapeutic effect is contradictory to reducing overheating in healthy tissues. We should make the temperature distribution more uniform and reduce the damage of healthy tissue caused by overheating. In the present work, we develop a simple computational method to analyze the temperature distribution during photothermal therapy at three levels (nanoscale, micron scale, and millimeter scale), and investigate the effects of nanoparticle size, volume fraction, light intensity, and irradiation shape on temperature distribution. We find that it is difficult to achieve good therapeutic effect just by adjusting the volume fraction of nanoparticles and light intensity. To achieve good therapeutic effect, we propose a new irradiation shape, spot array light. This method can achieve a better temperature distribution by easily regulating the positions of spots for the tumor with a large aspect ratio or a small one. In addition, the method of irradiation with spot array light can better reduce the overheating at the bottom and top of the tumor than the full-coverage light or others such as ring light. This theoretical work presents a simple method to investigate the effects of irradiation shape on therapy and provides a far more controlled way to improve the efficacy of photothermal therapy.
基于纳米颗粒的光热疗法是一种很有前景的癌症治疗方法。然而，在实际应用中仍存在许多限制。在光热疗法中，提高治疗效果与减少健康组织过热是相互矛盾的。我们应使温度分布更均匀，并减少过热对健康组织造成的损伤。在本工作中，我们开发了一种简单的计算方法，用于在三个层面（纳米尺度、微米尺度和毫米尺度）分析光热疗法期间的温度分布，并研究纳米颗粒尺寸、体积分数、光强度和照射形状对温度分布的影响。我们发现仅通过调整纳米颗粒的体积分数和光强度很难实现良好的治疗效果。为了实现良好的治疗效果，我们提出了一种新的照射形状，即点阵列光。该方法通过轻松调节大纵横比或小纵横比肿瘤的光斑位置，能够实现更好的温度分布。此外，与全覆盖光或环形光等其他照射方式相比，点阵列光照射方法能更好地减少肿瘤底部和顶部的过热现象。这项理论工作提出了一种研究照射形状对治疗效果影响的简单方法，并提供了一种更可控的方式来提高光热疗法的疗效。
