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发育期的染料木黄酮对雄性和雌性大鼠促肾上腺皮质激素原表达的影响存在差异。

Genistein during Development Alters Differentially the Expression of POMC in Male and Female Rats.

作者信息

Fernandez-Garcia Jose Manuel, Carrillo Beatriz, Tezanos Patricia, Collado Paloma, Pinos Helena

机构信息

Departamento de Psicobiología, Facultad Psicología, Universidad Nacional de Educación a Distancia (UNED), 28040 Madrid, Spain.

Instituto Mixto de Investigación Escuela Nacional de Sanidad-UNED (IMIENS), 28040 Madrid, Spain.

出版信息

Metabolites. 2021 May 2;11(5):293. doi: 10.3390/metabo11050293.

DOI:10.3390/metabo11050293
PMID:34063209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8147459/
Abstract

Phytoestrogens are considered beneficial for health, but some studies have shown that they may cause adverse effects. This study investigated the effects of genistein administration during the second week of life on energy metabolism and on the circuits regulating food intake. Two different genistein doses, 10 or 50 µg/g, were administered to male and female rats from postnatal day (P) 6 to P13. Physiological parameters, such as body weight and caloric intake, were then analyzed at P90. Moreover, proopiomelanocortin (POMC) expression in the arcuate nucleus (Arc) and orexin expression in the dorsomedial hypothalamus (DMH), perifornical area (PF) and lateral hypothalamus (LH) were studied. Our results showed a delay in the emergence of sex differences in the body weight in the groups with higher genistein doses. Furthermore, a significant decrease in the number of POMC-immunoreactive (POMC-ir) cells in the Arc in the two groups of females treated with genistein was observed. In contrast, no alteration in orexin expression was detected in any of the structures analyzed in either males or females. In conclusion, genistein can modulate estradiol's programming actions on the hypothalamic feeding circuits differentially in male and female rats during development.

摘要

植物雌激素被认为对健康有益，但一些研究表明它们可能会产生不良影响。本研究调查了在出生后第二周给予染料木黄酮对能量代谢以及对调节食物摄入的神经回路的影响。从出生后第6天（P6）至第13天（P13），对雄性和雌性大鼠给予两种不同剂量的染料木黄酮，分别为10或50μg/g。然后在P90时分析体重和热量摄入等生理参数。此外，还研究了弓状核（Arc）中阿黑皮素原（POMC）的表达以及背内侧下丘脑（DMH）、穹窿周区（PF）和外侧下丘脑（LH）中食欲素的表达。我们的结果显示，染料木黄酮剂量较高的组中，体重性别差异的出现有所延迟。此外，在接受染料木黄酮治疗的两组雌性大鼠的Arc中，观察到POMC免疫反应性（POMC-ir）细胞数量显著减少。相比之下，在雄性或雌性大鼠的任何分析结构中均未检测到食欲素表达的改变。总之，在发育过程中，染料木黄酮可以对雄性和雌性大鼠下丘脑进食回路中雌二醇的编程作用产生不同的调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db1/8147459/047e52aec16c/metabolites-11-00293-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db1/8147459/8e85a6a2027e/metabolites-11-00293-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db1/8147459/d7465bc0f5c6/metabolites-11-00293-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db1/8147459/047e52aec16c/metabolites-11-00293-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db1/8147459/8e85a6a2027e/metabolites-11-00293-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db1/8147459/d7465bc0f5c6/metabolites-11-00293-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db1/8147459/047e52aec16c/metabolites-11-00293-g003.jpg

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Use of Soy-Based Formulas and Cow's Milk Allergy: Lights and Shadows.大豆配方奶粉的使用与牛奶过敏：利弊分析
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