Thomson J F, Grahn D
Division of Biological and Medical Research, Argonne National Laboratory, Illinois 60439-4833.
Radiat Res. 1988 Aug;115(2):347-60.
A total of 6316 B6CF1 mice were exposed to 60 equal once-weekly doses of 0.85-MeV fission neutrons (0.033 to 0.67 cGy per weekly fraction) or 60Co gamma rays (1.67 to 10 cGy per weekly fraction) and were observed until they died. The mean aftersurvival times showed that the dose-response curves for both neutron and gamma-ray exposures were indistinguishable from linear over all doses except the highest neutron dose. The relative biological effectiveness (RBE) for neutrons, calculated as the ratio of the initial slopes of the dose-response curves, was about 20 for both males and females. Essentially the same value was obtained by a number of other analyses of the data. Virtually all of the radiation-specific excess mortality could be attributed to tumors; after decrementation of the population for nontumor deaths, the value of the RBE was not significantly changed.
总共6316只B6CF1小鼠接受了60次每周一次的等量照射，分别为0.85兆电子伏裂变中子（每周剂量为0.033至0.67厘戈瑞）或60钴γ射线（每周剂量为1.67至10厘戈瑞），并观察至其死亡。平均存活时间表明，除最高中子剂量外，中子和γ射线照射的剂量反应曲线在所有剂量下均与线性曲线无差异。以剂量反应曲线初始斜率之比计算的中子相对生物效应（RBE），雄性和雌性均约为20。通过对数据的其他一些分析也得到了基本相同的值。几乎所有辐射特异性的额外死亡率都可归因于肿瘤；在扣除非肿瘤死亡的种群数量后，RBE值没有显著变化。
