Liang Jing, Han Rongrong, Zhou Bing
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University, Beijing 100191, China.
School of Engineering Medicine, Beihang University, Beijing 100191, China.
Biology (Basel). 2021 May 11;10(5):424. doi: 10.3390/biology10050424.
Stroke is one of the leading causes of death and permanent disability worldwide. Ischemic preconditioning (IPC) is an endogenous protective strategy, which has been reported to exhibit a significant neuroprotective effect in reducing the incidence of ischemic stroke. However, the underlying neuroprotective mechanisms of IPC remain elusive. An increased understanding of the pathogenic mechanisms of stroke and IPC serves to highlight the importance of metabolic reprogramming. In this review, we summarize the metabolic disorder and metabolic plasticity in the incidence and progression of ischemic stroke. We also elaborate how IPC fully mobilizes the metabolic reprogramming to maintain brain metabolic homeostasis, especially for energy and redox homeostasis, and finally protects brain function in the event of an ischemic stroke.
中风是全球主要的死亡和永久性残疾原因之一。缺血预处理（IPC）是一种内源性保护策略，据报道在降低缺血性中风发病率方面具有显著的神经保护作用。然而，IPC潜在的神经保护机制仍不清楚。对中风和IPC致病机制的深入了解凸显了代谢重编程的重要性。在本综述中，我们总结了缺血性中风发生和发展过程中的代谢紊乱和代谢可塑性。我们还阐述了IPC如何充分调动代谢重编程以维持脑代谢稳态，特别是能量和氧化还原稳态，并最终在缺血性中风发生时保护脑功能。
