Laboratory of Virus Immunology, Institute for Frontier Life and Medical Science, Kyoto University, Kyoto 606-8507, Japan.
Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8507, Japan.
Viruses. 2021 May 11;13(5):876. doi: 10.3390/v13050876.
Viral non-structural proteins, such as NSs of the newly emerging severe fever with thrombocytopenia syndrome virus, are well established virulence factors, mediating viral pathogenesis and disease progression through various mechanisms. NSs has been described as a potent interferon antagonist and NF-κB agonist, two divergent signaling pathways in many immune responses upon a viral encounter. In this review, we highlight the many mechanisms used by NSs on the host that promote viral replication and hyper-inflammation. Understanding these host-pathogen interactions is crucial for antiviral therapy development.
病毒非结构蛋白，如新型出现的发热伴血小板减少综合征病毒的 NSs，是已经确定的毒力因子，通过多种机制介导病毒发病机制和疾病进展。NSs 已被描述为一种有效的干扰素拮抗剂和 NF-κB 激动剂，这是病毒感染后许多免疫反应中的两条不同的信号通路。在这篇综述中，我们强调了 NSs 在宿主中促进病毒复制和过度炎症的许多机制。了解这些宿主-病原体相互作用对于抗病毒治疗的发展至关重要。
