Goncalves Lauren N, van den Hoven Pim, van Schaik Jan, Leeuwenburgh Laura, Hendricks Cas H F, Verduijn Pieter S, van der Bogt Koen E A, van Rijswijk Carla S P, Schepers Abbey, Vahrmeijer Alexander L, Hamming Jaap F, van der Vorst Joost R
Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.
Life (Basel). 2021 May 11;11(5):433. doi: 10.3390/life11050433.
(1) Background: Near-infrared fluorescence imaging is a technique capable of assessing tissue perfusion and has been adopted in various fields including plastic surgery, vascular surgery, coronary arterial disease, and gastrointestinal surgery. While the usefulness of this technique has been broadly explored, there is a large variety in the calculation of perfusion parameters. In this systematic review, we aim to provide a detailed overview of current perfusion parameters, and determine the perfusion parameters with the most potential for application in near-infrared fluorescence imaging. (2) Methods: A comprehensive search of the literature was performed in Pubmed, Embase, Medline, and Cochrane Review. We included all clinical studies referencing near-infrared perfusion parameters. (3) Results: A total of 1511 articles were found, of which, 113 were suitable for review, with a final selection of 59 articles. Near-infrared fluorescence imaging parameters are heterogeneous in their correlation to perfusion. Time-related parameters appear superior to absolute intensity parameters in a clinical setting. (4) Conclusions: This literature review demonstrates the variety of parameters selected for the quantification of perfusion in near-infrared fluorescence imaging.
(1) 背景：近红外荧光成像技术能够评估组织灌注情况，已被应用于整形外科、血管外科、冠状动脉疾病及胃肠外科等多个领域。尽管该技术的实用性已得到广泛探索，但灌注参数的计算方法却多种多样。在本系统综述中，我们旨在详细概述当前的灌注参数，并确定在近红外荧光成像中最具应用潜力的灌注参数。(2) 方法：在PubMed、Embase、Medline和Cochrane综述中对文献进行全面检索。我们纳入了所有引用近红外灌注参数的临床研究。(3) 结果：共检索到1511篇文章，其中113篇适合综述，最终筛选出59篇文章。近红外荧光成像参数与灌注的相关性存在异质性。在临床环境中，与时间相关的参数似乎优于绝对强度参数。(4) 结论：本文献综述展示了近红外荧光成像中用于量化灌注的参数的多样性。
