Head of Department of Oral and Maxillofacial Surgery, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Ludwig-Maximilians-University, 80337 Munich, Germany.
Medicina (Kaunas). 2021 May 9;57(5):463. doi: 10.3390/medicina57050463.
Medication-related osteonecrosis of the jaw (MRONJ) has become a well-known side effect of antiresorptive, and antiangiogenic drugs commonly used in cancer management. Despite a considerable amount of literature addressing MRONJ, it is still widely accepted that the underlying pathomechanism of MRONJ is unclear. However, several clinical and preclinical studies indicate that infection seems to have a major role in the pathogenesis of MRONJ. Although there is no conclusive evidence for the infection hypothesis yet, available data have shown a robust association between local infection and MRONJ development. This observation is very critical in order to implement policies to reduce the risk of MRONJ in patients under antiresorptive drugs. This critical review was conducted to collect the most reliable evidence regarding the link between local infection and MRONJ pathogenesis.
药物相关性颌骨坏死（MRONJ）已成为癌症治疗中常用的抗吸收和抗血管生成药物的一种已知副作用。尽管有相当多的文献涉及 MRONJ，但人们仍然普遍认为 MRONJ 的潜在发病机制尚不清楚。然而，一些临床和临床前研究表明，感染似乎在 MRONJ 的发病机制中起主要作用。尽管目前还没有关于感染假说的确凿证据，但现有数据表明局部感染与 MRONJ 发展之间存在很强的关联。为了制定降低抗吸收药物患者 MRONJ 风险的政策，这一观察结果非常关键。进行这项关键性综述是为了收集关于局部感染与 MRONJ 发病机制之间联系的最可靠证据。
