Athanasiou Labrini V, Papatsiros Vasileios G, Spanou Victoria M, Katsogiannou Eleni G, Dedousi Anna
Department of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
Veterinary Research Institute, HAO-Demeter, 57001 Thessaloniki, Greece.
Microorganisms. 2021 May 20;9(5):1097. doi: 10.3390/microorganisms9051097.
and affect both humans and animals worldwide. To investigate their seroprevalence and differences in seropositivity between pigs vaccinated and unvaccinated against porcine circovirus 2 (PCV2), as well as differences in muscle enzyme activity between seropositive and seronegative pigs, blood samples were collected from 380 sows. Antibodies against and were detected by an indirect immunofluorescence antibody (IFA) assay, while the activities of creatine kinase (CK) and aspartate aminotransferase (AST) were biochemically assessed. Out of the 364 sows finally included in the study, 4.4%, 3.5%, and 0.5% were seropositive to , , or both. A significantly higher percentage of seropositivity against and/or in PCV2 unvaccinated pigs compared with vaccinated pigs was observed. Increased serum activities of CK and AST were detected in 71.43% and 100% of only against (T+) and 63.64% and 90.91% of only against (N+) seropositive sows, respectively, and were significantly higher compared to seronegative animals. and seropositivity, especially in presumed immunocompromised pigs, and the evidence of muscle damage highlight their importance as a zoonotic pathogen and animal model of human infection, respectively.
并影响全球范围内的人类和动物。为了调查猪圆环病毒2型（PCV2）疫苗接种猪和未接种猪之间的血清阳性率及其血清阳性差异，以及血清阳性猪和血清阴性猪之间肌肉酶活性的差异，采集了380头母猪的血样。通过间接免疫荧光抗体（IFA）检测抗[具体病毒名称1]和抗[具体病毒名称2]的抗体，同时对肌酸激酶（CK）和天冬氨酸转氨酶（AST）的活性进行生化评估。在最终纳入研究的364头母猪中，4.4%、3.5%和0.5%分别对[具体病毒名称1]、[具体病毒名称2]或两者血清呈阳性。与接种疫苗的猪相比，未接种PCV2疫苗的猪对[具体病毒名称1]和/或[具体病毒名称2]的血清阳性率显著更高。仅抗[具体病毒名称1]（T+）的血清阳性母猪中，71.43%和100%检测到CK和AST血清活性升高，仅抗[具体病毒名称2]（N+）的血清阳性母猪中，63.64%和90.91%检测到CK和AST血清活性升高，且与血清阴性动物相比显著更高。[具体病毒名称1]和[具体病毒名称2]血清阳性，特别是在假定免疫功能低下的猪中，以及肌肉损伤的证据分别突出了它们作为人畜共患病原体和人类感染动物模型的重要性。
