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本文引用的文献

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Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment.正在接受新冠病毒预防和治疗研究的膳食补充剂与营养保健品
mSystems. 2021 May 4;6(3):e00122-21. doi: 10.1128/mSystems.00122-21.
2
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.一项随机临床试验:单次高剂量维生素 D3 对中重度 COVID-19 患者住院时间的影响。
JAMA. 2021 Mar 16;325(11):1053-1060. doi: 10.1001/jama.2020.26848.
3
Malnutrition Prolongs the Hospitalization of Patients with COVID-19 Infection: A Clinical Epidemiological Analysis.营养不良延长 COVID-19 感染患者的住院时间:临床流行病学分析。
J Nutr Health Aging. 2021;25(3):369-373. doi: 10.1007/s12603-020-1541-y.
4
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection.低水平的维生素C和维生素C转运蛋白失调可能与新冠病毒感染的严重程度有关。
Aging Dis. 2021 Feb 1;12(1):14-26. doi: 10.14336/AD.2020.0918. eCollection 2021 Feb.
5
A hidden side of the COVID-19 pandemic in children: the double burden of undernutrition and overnutrition.儿童 COVID-19 大流行的一个隐藏方面:营养不足和营养过剩的双重负担。
Int J Equity Health. 2021 Jan 22;20(1):44. doi: 10.1186/s12939-021-01390-w.
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Obesity in COVID-19: A Systematic Review and Meta-analysis.肥胖与 COVID-19 关系的系统评价和荟萃分析。
Ann Acad Med Singap. 2020 Dec;49(12):996-1008. doi: 10.47102/annals-acadmedsg.2020299.
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Pilot trial of high-dose vitamin C in critically ill COVID-19 patients.大剂量维生素C用于危重症COVID-19患者的初步试验。
Ann Intensive Care. 2021 Jan 9;11(1):5. doi: 10.1186/s13613-020-00792-3.
8
The path ahead: From global pandemic to health promotion.前进之路:从全球大流行到健康促进。
Prev Med Rep. 2020 Dec 8;21:101271. doi: 10.1016/j.pmedr.2020.101271. eCollection 2021 Mar.
9
Prevalence of malnutrition in coronavirus disease 19: the NUTRICOV study.2019 冠状病毒病中的营养不良患病率:NUTRICOV 研究。
Br J Nutr. 2021 Nov 14;126(9):1296-1303. doi: 10.1017/S0007114520005127. Epub 2020 Dec 21.
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High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study.高剂量胆钙化醇助推疗法与 COVID-19 患者的死亡率降低相关:一项横断面多中心观察性研究。
Nutrients. 2020 Dec 11;12(12):3799. doi: 10.3390/nu12123799.

携手应对 COVID-19 大流行期间生命极限处的营养不足问题。

Joint Effort towards Preventing Nutritional Deficiencies at the Extremes of Life during COVID-19.

机构信息

Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.

Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, 20138 Milan, Italy.

出版信息

Nutrients. 2021 May 12;13(5):1616. doi: 10.3390/nu13051616.

DOI:10.3390/nu13051616
PMID:34065864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8150599/
Abstract

The COVID-19 (Coronavirus disease 2019) pandemic is posing a threat to communities and healthcare systems worldwide. Malnutrition, in all its forms, may negatively impact the susceptibility and severity of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection in both children and older adults. Both undernutrition and obesity have been evoked as conditions associated with a higher susceptibility to the infection and poor prognosis. In turn, the COVID-19 infection may worsen the nutritional status through highly catabolic conditions, exposing individuals to the risk of malnutrition, muscle wasting, and nutritional deficiencies. Accordingly, the relationship between malnutrition and COVID-19 is likely to be bidirectional. Furthermore, the modification of nutritional behaviors and physical activity, required to limit the spread of the virus, are posing a challenge to health at both the extremes of life. Thus far, even the most advanced healthcare systems have failed to address the alarming consequences of malnutrition posed by this pandemic. If not properly addressed, we may run the risk that new and old generations will experience the consequences of COVID-19 related malnutrition.

摘要

新型冠状病毒(COVID-19)大流行正在对全球社区和医疗体系构成威胁。各种形式的营养不良都可能对儿童和老年人中严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)感染的易感性和严重程度产生负面影响。营养不足和肥胖都被认为是与更高的感染易感性和不良预后相关的条件。反过来,COVID-19 感染可能通过高度分解代谢的情况使营养状况恶化,使个体面临营养不良、肌肉消耗和营养缺乏的风险。因此,营养不良和 COVID-19 之间的关系可能是双向的。此外,为了限制病毒的传播而改变营养行为和体育活动,这对生命两端的健康都构成了挑战。到目前为止,即使是最先进的医疗体系也未能解决这场大流行所带来的营养不良的惊人后果。如果不加以妥善处理,我们可能会面临新老两代人都将遭受与 COVID-19 相关营养不良后果的风险。