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携手应对 COVID-19 大流行期间生命极限处的营养不足问题。

Joint Effort towards Preventing Nutritional Deficiencies at the Extremes of Life during COVID-19.

机构信息

Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.

Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, 20138 Milan, Italy.

出版信息

Nutrients. 2021 May 12;13(5):1616. doi: 10.3390/nu13051616.

Abstract

The COVID-19 (Coronavirus disease 2019) pandemic is posing a threat to communities and healthcare systems worldwide. Malnutrition, in all its forms, may negatively impact the susceptibility and severity of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection in both children and older adults. Both undernutrition and obesity have been evoked as conditions associated with a higher susceptibility to the infection and poor prognosis. In turn, the COVID-19 infection may worsen the nutritional status through highly catabolic conditions, exposing individuals to the risk of malnutrition, muscle wasting, and nutritional deficiencies. Accordingly, the relationship between malnutrition and COVID-19 is likely to be bidirectional. Furthermore, the modification of nutritional behaviors and physical activity, required to limit the spread of the virus, are posing a challenge to health at both the extremes of life. Thus far, even the most advanced healthcare systems have failed to address the alarming consequences of malnutrition posed by this pandemic. If not properly addressed, we may run the risk that new and old generations will experience the consequences of COVID-19 related malnutrition.

摘要

新型冠状病毒(COVID-19)大流行正在对全球社区和医疗体系构成威胁。各种形式的营养不良都可能对儿童和老年人中严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)感染的易感性和严重程度产生负面影响。营养不足和肥胖都被认为是与更高的感染易感性和不良预后相关的条件。反过来,COVID-19 感染可能通过高度分解代谢的情况使营养状况恶化,使个体面临营养不良、肌肉消耗和营养缺乏的风险。因此,营养不良和 COVID-19 之间的关系可能是双向的。此外,为了限制病毒的传播而改变营养行为和体育活动,这对生命两端的健康都构成了挑战。到目前为止,即使是最先进的医疗体系也未能解决这场大流行所带来的营养不良的惊人后果。如果不加以妥善处理,我们可能会面临新老两代人都将遭受与 COVID-19 相关营养不良后果的风险。

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