Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Int J Environ Res Public Health. 2021 May 12;18(10):5116. doi: 10.3390/ijerph18105116.
Oncotype DX (ODX) is a valid test of breast cancer (BC) recurrence risk and chemotherapy benefit. The purpose of this study was to examine prevalence of and factors associated with receipt of ODX testing among eligible Latinas/Hispanics diagnosed with BC. Sociodemographic and tumor data of BC cases diagnosed between 2008 and 2017 among Latina/Hispanic women ( = 5777) were from the New Jersey State Cancer Registry (NJSCR). Eligibility for ODX testing were based on National Comprehensive Cancer Network guidelines. Multivariable logistic regression models of ODX receipt among eligible women were used to estimate adjusted odds ratios (AOR) and 95% confidence intervals (CI) by demographic and clinicopathologic factors. One-third of Latinas/Hispanics diagnosed with BC were eligible for ODX testing. Among the eligible, 60.9% received ODX testing. Older age (AOR 0.08, 95% CI: 0.04, 0.14), low area-level SES (AOR 0.58, 95% CI: 0.42, 0.52), and being uninsured (AOR 0.58, 95% CI: 0.39, 0.86) were associated with lower odds of ODX testing. While there was relatively high ODX testing among eligible Latina/Hispanic women with BC in New Jersey, our findings suggest that age, insurance status, and area-level SES contribute to unequal access to genetic testing in this group, which might impact BC outcomes.
Oncotype DX（ODX）是一种有效的乳腺癌（BC）复发风险和化疗获益的检测方法。本研究的目的是检查在新泽西州被诊断为 BC 的合格拉丁裔/西班牙裔女性中，接受 ODX 检测的流行率和相关因素。2008 年至 2017 年间诊断为 BC 的拉丁裔/西班牙裔女性（n=5777）的社会人口统计学和肿瘤数据来自新泽西州癌症登记处（NJSCR）。ODX 检测的合格标准基于国家综合癌症网络指南。使用多变量逻辑回归模型来估计合格女性中 ODX 接受情况的调整优势比（AOR）和 95%置信区间（CI），按人口统计学和临床病理因素进行分层。三分之一的被诊断为 BC 的拉丁裔/西班牙裔女性有资格进行 ODX 检测。在合格者中，有 60.9%接受了 ODX 检测。年龄较大（AOR 0.08，95%CI：0.04，0.14）、低地区社会经济地位（AOR 0.58，95%CI：0.42，0.52）和没有保险（AOR 0.58，95%CI：0.39，0.86）与 ODX 检测的可能性较低相关。尽管新泽西州有相当多的合格拉丁裔/西班牙裔 BC 女性接受了 ODX 检测，但我们的研究结果表明，年龄、保险状况和地区社会经济地位是导致该人群中基因检测机会不平等的因素，这可能会影响 BC 的结局。
