Kumar Alip, Kheravii Sarbast K, Li Lily, Wu Shu-Biao
School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.
BASF Animal Nutrition, Asia Pacific, 7 Temasek Boulevard, Singapore 038987, Singapore.
Animals (Basel). 2021 May 17;11(5):1432. doi: 10.3390/ani11051432.
This study evaluated the potential of monoglyceride blend (MG) and buffered formic acid (FA) as alternatives to antibiotics in the performance and intestinal health of broilers under clinical necrotic enteritis (NE) challenge. A total of 544 as-hatched Ross 308 broiler chicks were randomly distributed to 32-floor pens housing 17 birds per pen. The four treatments were: NC-non-additive control; ZBS-antibiotic group supplemented with zinc bacitracin and salinomycin; MG-additive MG supplementation in the starter phase only; and MGFA-additive MG in starter phase and FA in grower and finisher phases. All birds were challenged with spp. and . Results showed that the NC group had lower BWG and higher FCR than the ZBS group in the grower and overall period ( < 0.05). The NC group had higher NE-caused mortality (days 14 to 17) than the ZBS group ( < 0.05). Birds fed MG had lower NE-caused mortality than the NC group ( < 0.05). Birds fed MG had upregulated jejunal tight junction protein1 () and immunoglobulin () on day 16 and improved gross energy digestibility on day 24 than the NC group ( < 0.05). These findings suggest that supplementation of MG may improve intestinal health and protect birds from clinical NE occurrence.
本研究评估了甘油单酯混合物（MG）和缓冲甲酸（FA）在临床坏死性肠炎（NE）挑战下对肉鸡生产性能和肠道健康的影响，以替代抗生素。总共544只刚出壳的罗斯308肉鸡雏鸡被随机分配到32个层笼中，每个笼子饲养17只鸡。四种处理方式分别为：NC-不添加任何添加剂的对照组；ZBS-添加杆菌肽锌和盐霉素的抗生素组；MG-仅在育雏期添加MG添加剂；MGFA-在育雏期添加MG添加剂，在生长育肥期添加FA。所有鸡只均受到[某种细菌名称1]和[某种细菌名称2]的攻击。结果表明，在生长育肥期和整个试验期，NC组的平均日增重（BWG）低于ZBS组，料重比（FCR）高于ZBS组（P<0.05）。NC组因NE导致的死亡率（第14至17天）高于ZBS组（P<0.05）。饲喂MG的鸡只因NE导致的死亡率低于NC组（P<0.05）。与NC组相比，饲喂MG的鸡在第16天空肠紧密连接蛋白1（[蛋白名称1]）和免疫球蛋白（[蛋白名称2]）上调，在第24天总能消化率提高（P<0.05）。这些结果表明，添加MG可能改善肠道健康，保护鸡只免受临床NE的发生。
