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长期新冠综合征?一项关于神经、心理和生理症状持续性的研究。

Long-COVID Syndrome? A Study on the Persistence of Neurological, Psychological and Physiological Symptoms.

作者信息

Orrù Graziella, Bertelloni Davide, Diolaiuti Francesca, Mucci Federico, Di Giuseppe Mariagrazia, Biella Marco, Gemignani Angelo, Ciacchini Rebecca, Conversano Ciro

机构信息

Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Via Savi, 10, 56126 Pisa, Italy.

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.

出版信息

Healthcare (Basel). 2021 May 13;9(5):575. doi: 10.3390/healthcare9050575.

Abstract

BACKGROUND

Emerging aspects of the Covid-19 clinical presentation are its long-term effects, which are characteristic of the so-called "long COVID". The aim of the present study was to investigate the prevalence of physical, psychological, and sleep disturbances and the quality of life in the general population during the ongoing pandemic.

METHODS

This study, based on an online survey, collected demographic data, information related to COVID-19, sleep disturbances, and quality of life data from 507 individuals. The level of sleep disturbances and quality of life was assessed through the Insomnia Severity Index (ISI) and the EuroQol-5D (EQ-5D), respectively.

RESULTS

In total, 507 individuals (M = 91 and F = 416 women) completed the online survey. The main symptoms associated with "long COVID" were headache, fatigue, muscle aches/myalgia, articular pains, cognitive impairment, loss of concentration, and loss of smell. Additionally, the subjects showed significant levels of insomnia ( < 0.05) and an overall reduced quality of life ( < 0.05).

CONCLUSIONS

The results of the study appear in line with recent publications, but uncertainty regarding the definition and specific features of "long COVID" remains. Further studies are needed in order to better define the clinical presentation of the "long COVID" condition and related targeted treatments.

摘要

背景

新冠病毒病临床表现的新出现的方面是其长期影响,这是所谓“长新冠”的特征。本研究的目的是调查在当前大流行期间普通人群中身体、心理和睡眠障碍的患病率以及生活质量。

方法

本研究基于一项在线调查,收集了507名个体的人口统计学数据、与新冠病毒病相关的信息、睡眠障碍以及生活质量数据。睡眠障碍水平和生活质量分别通过失眠严重程度指数(ISI)和欧洲五维健康量表(EQ-5D)进行评估。

结果

共有507名个体(男性91名,女性416名)完成了在线调查。与“长新冠”相关的主要症状为头痛、疲劳、肌肉疼痛/肌痛、关节疼痛、认知障碍、注意力不集中和嗅觉丧失。此外,受试者表现出显著的失眠水平(<0.05)和总体生活质量下降(<0.05)。

结论

该研究结果与近期出版物一致,但“长新冠”的定义和具体特征仍存在不确定性。需要进一步研究以更好地界定“长新冠”病症的临床表现及相关靶向治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2a/8152255/ab216f868d71/healthcare-09-00575-g001a.jpg

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