Endocrinology and Nutrition department, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain; Clinical Medicine department, Miguel Hernández University, Elche, Spain.
Unit of Infectious Diseases, Alicante General University Hospital, Alicante Institute of Health and Institute of Sanitary and Biomedical Research (ISABIAL), Alicante, Spain.
J Infect. 2021 Mar;82(3):378-383. doi: 10.1016/j.jinf.2021.01.004. Epub 2021 Jan 12.
This study aims to analyze the incidence of Post-acute COVID-19 syndrome (PCS) and its components, and to evaluate the acute infection phase associated risk factors.
A prospective cohort study of adult patients who had recovered from COVID-19 (27th February to 29th April 2020) confirmed by PCR or subsequent seroconversion, with a systematic assessment 10-14 weeks after disease onset. PCS was defined as the persistence of at least one clinically relevant symptom, or abnormalities in spirometry or chest radiology. Outcome predictors were analyzed by multiple logistic regression (OR; 95%CI).
Two hundred seventy seven patients recovered from mild (34.3%) or severe (65.7%) forms of SARS-CoV-2 infection were evaluated 77 days (IQR 72-85) after disease onset. PCS was detected in 141 patients (50.9%; 95%CI 45.0-56.7%). Symptoms were mostly mild. Alterations in spirometry were noted in 25/269 (9.3%), while in radiographs in 51/277 (18.9%). No baseline clinical features behaved as independent predictors of PCS development.
A Post-acute COVID-19 syndrome was detected in a half of COVID19 survivors. Radiological and spirometric changes were mild and observed in less than 25% of patients. No baseline clinical features behaved as independent predictors of Post-acute COVID-19 syndrome development.
本研究旨在分析新冠病毒感染后综合征（PCS）及其组成部分的发生率，并评估急性感染期相关的危险因素。
这是一项前瞻性队列研究，纳入了 2020 年 2 月 27 日至 4 月 29 日经 PCR 或后续血清转换确诊的 COVID-19 康复成年患者，在发病后 10-14 周进行系统评估。PCS 定义为至少存在一种临床相关症状，或肺功能或胸部影像学异常。采用多因素逻辑回归（OR；95%CI）分析结局预测因素。
277 例从 SARS-CoV-2 轻度（34.3%）或重度（65.7%）感染中康复的患者在发病后 77 天（IQR 72-85）进行了评估。141 例（50.9%；95%CI 45.0-56.7%）患者出现 PCS。症状大多较轻。269 例中有 25 例（9.3%）肺功能检查异常，277 例中有 51 例（18.9%）胸部影像学异常。基线临床特征均未成为 PCS 发展的独立预测因素。
COVID19 幸存者中有一半出现了新冠病毒感染后综合征。放射学和肺功能变化较轻，不到 25%的患者出现这些变化。基线临床特征均未成为 PCS 发展的独立预测因素。
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