Kwon Mi Jung, Kim Joo-Hee, Kim Ji Hee, Cho Seong Jin, Nam Eun Sook, Choi Hyo Geun
Division of Neuropathology, Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea.
Front Aging Neurosci. 2021 Dec 8;13:786337. doi: 10.3389/fnagi.2021.786337. eCollection 2021.
: Public health concerns regarding the potential link between osteoporosis and the increased occurrence of Alzheimer's disease (AD) and Parkinson's disease (PD) have been raised, but the results remain inconsistent and require further validation. Here, we investigated the long-term relationship of osteoporosis with the occurrence of AD/PD using data from a large-scale nationwide cohort. : This longitudinal follow-up study included 78,994 patients with osteoporosis and 78,994 controls from the Korean National Health Insurance Service-Health Screening Cohort database (2002-2015) who were matched using propensity score matching at a 1:1 ratio based on age, sex, income, and residential area. A Cox proportional hazard model was used to assess the association between osteoporosis and the occurrence of AD/PD after adjusting for multiple covariates. : During the follow-up period, AD occurred in 5,856 patients with osteoporosis and 3,761 controls (incidence rates: 10.4 and 6.8 per 1,000 person-years, respectively), and PD occurred in 1,397 patients and 790 controls (incidence rates: 2.4 and 1.4 per 1,000 person-years, respectively). The incidences of AD and PD were significantly higher in the osteoporosis group than in the matched control group. After adjustment, the osteoporosis group exhibited 1.27-fold and 1.49-fold higher occurrences of AD (95% confidence interval (CI) = 1.22-1.32) and PD (95% CI = 1.36-1.63) than the controls, respectively. The results of subgroup analyses supported the increased occurrence of AD and PD in patients with osteoporosis, independent of income, residential area, obesity, smoking, alcohol consumption, hyperlipidemia, hypertension, or blood glucose level. : Our results indicate that the presence of osteoporosis may increase the likelihood of developing two common neurodegenerative diseases in adults aged ≥40 years.
关于骨质疏松症与阿尔茨海默病（AD）和帕金森病（PD）发病率增加之间潜在联系的公共卫生问题已经引起关注，但结果仍不一致，需要进一步验证。在此，我们使用来自全国大规模队列的数据，研究了骨质疏松症与AD/PD发病的长期关系。
这项纵向随访研究纳入了韩国国民健康保险服务-健康筛查队列数据库（2002-2015年）中的78994例骨质疏松症患者和78994例对照，根据年龄、性别、收入和居住地区，以1:1的比例使用倾向评分匹配进行匹配。采用Cox比例风险模型，在调整多个协变量后评估骨质疏松症与AD/PD发病之间的关联。
在随访期间，5856例骨质疏松症患者和3761例对照发生了AD（发病率分别为每1000人年10.4例和6.8例），1397例患者和790例对照发生了PD（发病率分别为每1000人年2.4例和1.4例）。骨质疏松症组中AD和PD的发病率显著高于匹配的对照组。调整后，骨质疏松症组发生AD（95%置信区间（CI）=1.22-1.32）和PD（95%CI = 1.36-1.63）的发生率分别比对照组高1.27倍和1.49倍。亚组分析结果支持骨质疏松症患者中AD和PD的发生率增加，且不受收入、居住地区、肥胖、吸烟、饮酒、高脂血症、高血压或血糖水平的影响。
我们的结果表明，骨质疏松症的存在可能会增加40岁及以上成年人患两种常见神经退行性疾病的可能性。
