Hwang Youn-Hwan, Lee Ami, Kim Taesoo, Jang Seon-A, Ha Hyunil
Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea.
Korean Convergence Medicine Major KIOM, Korea University of Science & Technology (UST), 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Korea.
Plants (Basel). 2021 May 10;10(5):945. doi: 10.3390/plants10050945.
In traditional oriental medicines, and its resinous exudate (i.e., myrrh) are used as herbal remedies to treat various inflammatory and metabolic disorders. Until now, -derived herbal products are considered useful source for bioactive compounds to manage numerous human diseases. This study investigated the effects of water extract of resin (WCM) and its polysaccharide (WCM-PE) on modulatory effects of osteoclast differentiation and/or ovariectomized-induced bone loss. Oral administration of WCM (200 and 500 mg/kg/day for four weeks) notably decreased trabecular bone loss and lipid accumulation in the bone marrow cavity. WCM and WCM-PE dose-dependently inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and suppressed RANKL-mediated overexpression of c-Fos and nuclear factor of activated T cells, cytoplasmic 1, thereby downregulating osteoclast-specific gene (Atp6v0d2, DC-STAMP and cathepsin K) expression. Thus, our results suggest that WCM and WCM-PE are promising nutraceutical candidates for the management of osteoporosis in postmenopausal women.
在传统东方医学中，[植物名称]及其树脂状渗出物（即没药）被用作草药疗法来治疗各种炎症和代谢紊乱。到目前为止，[植物名称]衍生的草药产品被认为是管理众多人类疾病的生物活性化合物的有用来源。本研究调查了[植物名称]树脂水提取物（WCM）及其多糖（WCM-PE）对破骨细胞分化和/或去卵巢诱导的骨质流失的调节作用。口服WCM（200和500毫克/千克/天，持续四周）显著减少了小梁骨丢失和骨髓腔内的脂质积累。WCM和WCM-PE剂量依赖性地抑制核因子κB受体激活剂配体（RANKL）诱导的破骨细胞生成，并抑制RANKL介导的c-Fos和活化T细胞核因子细胞质1的过表达，从而下调破骨细胞特异性基因（Atp6v0d2、DC-STAMP和组织蛋白酶K）的表达。因此，我们的结果表明，WCM和WCM-PE是绝经后妇女骨质疏松症管理中有前景的营养保健品候选物。
