Mohammed Aiman Saleh A, Naveed Muhammad, Jost Norbert
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Interdisciplinary Excellence Centre, University of Szeged, Szeged, 6720 Hungary.
Department of Pharmacology, Faculty of Pharmacy, University of Aden, Aden, Yemen.
J Polym Environ. 2021;29(8):2359-2371. doi: 10.1007/s10924-021-02052-2. Epub 2021 Jan 27.
Polysaccharides are essential macromolecules which almost exist in all living forms, and have important biological functions, they are getting more attention because they exhibit a wide range of biological and pharmacological activities, such as anti-tumour, immunomodulatory, antimicrobial, antioxidant, anticoagulant, antidiabetic, antiviral, and hypoglycemia activities, making them one of the most promising candidates in biomedical and pharmaceutical fields. Polysaccharides can be obtained from many different sources, such as plants, microorganisms, algae, and animals. Due to their physicochemical properties, they are susceptible to physical and chemical modifications leading to enhanced properties, which is the basic concept for their diverse applications in biomedical and pharmaceutical fields. In this review, we will give insight into the most recent updated applications of polysaccharides and their potentialities as alternatives for traditional and conventional therapies. Challenges and limitations for polysaccharides in pharmaceutical utilities are discussed as well.
多糖是几乎存在于所有生命形式中的重要大分子，具有重要的生物学功能。它们因展现出广泛的生物学和药理活性，如抗肿瘤、免疫调节、抗菌、抗氧化、抗凝、抗糖尿病、抗病毒和降血糖活性等，而受到越来越多的关注，这使它们成为生物医学和制药领域最有前景的候选物质之一。多糖可以从许多不同来源获得，如植物、微生物、藻类和动物。由于其物理化学性质，它们易于进行物理和化学修饰，从而增强性能，这是它们在生物医学和制药领域广泛应用的基本概念。在本综述中，我们将深入探讨多糖的最新应用及其作为传统和常规疗法替代品的潜力。同时也讨论了多糖在药物应用中的挑战和局限性。
