Lech Marta, Mastalska-Popławska Joanna, Laska Jadwiga
Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, 30-059 Kraków, Poland.
Materials (Basel). 2021 May 10;14(9):2459. doi: 10.3390/ma14092459.
Polylactide and aliphatic polyurethane are biodegradable synthetic polymers which are broadly used as biomaterials in regenerative medicine for implants and scaffolds for tissue engineering. In this paper, the detailed studies of the fabrication of the electrospun fibers of polyurethane/polylactide mixtures were described. The influence of the used solvent (dimethylformamide (DMF)) and diluents (acetone and dichloromethane (DCM)) on the rheological parameters and electrospinning of the described mixtures was examined. Rheological studies showed that polyure-thane/polylactide mixtures have mostly non-Newtonian character, strongly influenced by the diluent. Solutions containing 50 wt.% or more of polyurethane became less viscous after the addition of DCM or acetone, whereas those with bigger amount of polylactide showed higher viscosity after the addition of DCM and lower viscosity after the addition of acetone. Optimized electrospinning process has been elaborated. Fibers with diameters from 250 nm up to 1 µm have been produced and compared. Pure acetone worsened the electrospinning process, but the more DCM was in the mixture, the thinner and more aligned fibers were produced.
聚乳酸和脂肪族聚氨酯是可生物降解的合成聚合物，在再生医学中被广泛用作组织工程植入物和支架的生物材料。本文描述了聚氨酯/聚乳酸混合物电纺纤维制备的详细研究。研究了所用溶剂（二甲基甲酰胺（DMF））和稀释剂（丙酮和二氯甲烷（DCM））对所述混合物流变参数和电纺的影响。流变学研究表明，聚氨酯/聚乳酸混合物大多具有非牛顿特性，受稀释剂影响很大。加入DCM或丙酮后，含50 wt.%或更多聚氨酯的溶液粘度降低，而含大量聚乳酸的溶液在加入DCM后粘度升高，加入丙酮后粘度降低。已制定了优化的电纺工艺。制备并比较了直径从250 nm到1 µm的纤维。纯丙酮会使电纺过程变差，但混合物中DCM越多，产生的纤维越细且排列越整齐。
