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民间医学“五贼油”（Olejek Pięciu Złodziei）成分的多学科研究。

Multidisciplinary Studies of Folk Medicine "Five Thieves' Oil" (Olejek Pięciu Złodziei) Components.

机构信息

Department of Physics and Biophysics, Faculty of Food Science and Nutrition, Poznań University of Life Sciences, Wojska Polskiego 38/42, 60-637 Poznań, Poland.

Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-637 Poznań, Poland.

出版信息

Molecules. 2021 May 14;26(10):2931. doi: 10.3390/molecules26102931.

DOI:10.3390/molecules26102931
PMID:34069178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8155914/
Abstract

To meet the growing interest in natural antibacterial agents, we evaluated the physicochemical and biological properties of the folk medicine known as "five thieves' oil" (Polish name: olejek pięciu złodziei). Five thieves' oil consists of a mixture of five oils: rosemary, lemon, clove, eucalyptus, and cinnamon. In this study, we performed gas chromatography, FTIR, and UV-vis spectroscopic analysis, as well as L-a-b color tests, contact angle determination, and surface tension determination. To verify its antibacterial activity, the metabolic activity and changes in cell membrane permeability of bacteria of the genus were studied. As a result, it was found that among the constituent oils, the oils of clove and cinnamon were the least volatile and, at the same time, had the strongest antibacterial activity. However, a mix of all the oils also showed comparable activity, which was even more pronounced for the oils after 4 weeks of aging. This effect can be linked to the high content of terpene derivatives such as eugenol and cinnamaldehyde, which can cause changes in bacterial membrane permeability, affecting cell activity and survival. This study is the first to characterize the constituents of the popular folk medicine five thieves' oil, confirming and explaining its strong antibacterial activity, thus constituting a significant contribution to contemporary health education.

摘要

为满足人们对天然抗菌剂日益增长的兴趣，我们评估了民间药物“五贼油”（波兰语：olejek pięciu złodziei）的物理化学和生物学特性。五贼油由五种油组成：迷迭香、柠檬、丁香、桉树和肉桂。在这项研究中，我们进行了气相色谱、FTIR 和 UV-vis 光谱分析，以及 L-a-b 颜色测试、接触角测定和表面张力测定。为了验证其抗菌活性，研究了属细菌的代谢活性和细胞膜通透性的变化。结果发现，在组成油中，丁香油和肉桂油的挥发性最低，同时具有最强的抗菌活性。然而，所有油的混合物也表现出相当的活性，在经过 4 周老化后，这种活性更为明显。这种效果可以归因于萜烯衍生物如丁香酚和肉桂醛的高含量，它们会导致细菌细胞膜通透性的变化，从而影响细胞的活性和存活。本研究首次对流行民间药物五贼油的成分进行了表征，证实并解释了其强烈的抗菌活性，从而为当代健康教育做出了重要贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/a57c4b9386b2/molecules-26-02931-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/6c22bb88f1aa/molecules-26-02931-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/588abe41d7c1/molecules-26-02931-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/47727c450970/molecules-26-02931-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/9975477d5d9d/molecules-26-02931-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/e40948dfa695/molecules-26-02931-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/f943f2687fe2/molecules-26-02931-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/7ebb16fb770b/molecules-26-02931-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/cd2df15472a1/molecules-26-02931-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/a57c4b9386b2/molecules-26-02931-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/6c22bb88f1aa/molecules-26-02931-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/588abe41d7c1/molecules-26-02931-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/47727c450970/molecules-26-02931-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/9975477d5d9d/molecules-26-02931-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/e40948dfa695/molecules-26-02931-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/f943f2687fe2/molecules-26-02931-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/7ebb16fb770b/molecules-26-02931-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/cd2df15472a1/molecules-26-02931-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b610/8155914/a57c4b9386b2/molecules-26-02931-g009.jpg

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