慢性阻塞性肺疾病患者睡眠期间氧合情况的预测
Prediction of oxygenation during sleep in patients with chronic obstructive lung disease.
作者信息
McKeon J L, Murree-Allen K, Saunders N A
机构信息
Department of Thoracic Medicine, Royal Newcastle Hospital, New South Wales, Australia.
出版信息
Thorax. 1988 Apr;43(4):312-7. doi: 10.1136/thx.43.4.312.
The accuracy of a prediction equation for assessing the lowest arterial oxygen saturation (SaO2) during sleep was determined in 24 consecutive patients with chronic obstructive lung disease referred for assessment for home oxygen therapy. Subjects had a mean (SD) FEV1 of 0.81 (0.31) litre and an FEV1/FVC of 37% (12%). There was reasonable agreement between predicted and measured values (mean difference [predicted-measured] = -2.5%) but the prediction was not precise as the 95% confidence interval for the difference was +8% to -13%. The duration of arterial oxygen desaturation, defined as the percentage of total sleep time spent below a given SaO2, was not predicted accurately. It is concluded that nocturnal arterial oxygen desaturation in individual patients with chronic obstructive lung disease cannot be predicted from "awake" measurements with sufficient accuracy to be clinically useful.
对24例因家庭氧疗评估而转诊的慢性阻塞性肺疾病患者，测定了评估睡眠期间最低动脉血氧饱和度（SaO2）的预测方程的准确性。受试者的平均（标准差）第1秒用力呼气容积（FEV1）为0.81（0.31）升，FEV1/用力肺活量（FVC）为37%（12%）。预测值与测量值之间存在合理的一致性（平均差异[预测值-测量值]=-2.5%），但由于差异的95%置信区间为+8%至-13%，所以预测并不精确。动脉血氧饱和度降低的持续时间（定义为低于给定SaO2的总睡眠时间百分比）无法准确预测。得出的结论是，仅根据“清醒时”的测量结果，无法足够准确地预测个体慢性阻塞性肺疾病患者的夜间动脉血氧饱和度降低情况，因此在临床上并无实用价值。
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