Pereira Osvaldo, Kowaltowski Alicia J
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, SP, Brazil.
Molecules. 2021 May 14;26(10):2935. doi: 10.3390/molecules26102935.
The existence of a K cycle in mitochondria has been predicted since the development of the chemiosmotic theory and has been shown to be crucial for several cellular phenomena, including regulation of mitochondrial volume and redox state. One of the pathways known to participate in K cycling is the ATP-sensitive K channel, MitoK. This channel was vastly studied for promoting protection against ischemia reperfusion when pharmacologically activated, although its molecular identity remained unknown for decades. The recent molecular characterization of MitoK has opened new possibilities for modulation of this channel as a mechanism to control cellular processes. Here, we discuss different strategies to control MitoK activity and consider how these could be used as tools to regulate metabolism and cellular events.
自从化学渗透理论发展以来，线粒体中钾循环的存在就已被预测，并且已证明它对多种细胞现象至关重要，包括线粒体体积和氧化还原状态的调节。已知参与钾循环的途径之一是ATP敏感性钾通道，即线粒体钾通道（MitoK）。尽管其分子身份数十年来一直未知，但该通道在药理学激活时对预防缺血再灌注具有促进保护作用，因此得到了广泛研究。线粒体钾通道（MitoK）最近的分子特征为调节该通道作为控制细胞过程的机制开辟了新的可能性。在这里，我们讨论了控制线粒体钾通道（MitoK）活性的不同策略，并考虑了如何将这些策略用作调节代谢和细胞事件的工具。
