Pietras-Baczewska Agata, Nowomiejska Katarzyna, Brzozowska Agnieszka, Toro Mario Damiano, Załuska Wojciech, Sztanke Małgorzata, Sztanke Krzysztof, Rejdak Robert
Chair and Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-059 Lublin, Poland.
Department of Mathematics and Medical Biostatistics, Medical University of Lublin, 20-059 Lublin, Poland.
Life (Basel). 2021 May 19;11(5):453. doi: 10.3390/life11050453.
(1) Background: The aim of the study was to test the hypothesis that the antioxidant status in the vitreous body of eyes, which had been vitrectomized due to rhegmatogenous retinal detachment (RRD) with or without proliferative vitreoretinopathy (PVR), is higher than in eyes vitrectomized due to other retinal diseases. (2) Methods: four patient groups were analyzed: 22 eyes of patients with RRD without PVR, 27 eyes with RRD and PVR, 22 eyes with macular hole (MH) and 10 eyes with epiretinal membrane (ERM). Spectrophotometric methods were used to determine the total antioxidant status (TAS) values as well as superoxide dismutase (SOD) and glutathione reductase (GR) activities in the vitreous fluid samples. (3) Results: no significant differences in TAS values and antioxidant enzyme activities were observed among patient with RRD with and without PVR and with MH and ERM. The longer the duration of RRD leading to PVR and better postoperative visual acuity, the higher the TAS level. No significant differences were found between "macula on" and "macula off" subgroups within the RRD group and the RRD combined with PVR group. (4) Conclusions: The preliminary results do not support the thesis that the antioxidant status of vitrectomized eyes is different in patients with RRD with or without PVR in comparison to patients with MH and ERM. In patients with RRD, PVR presence and detached macula do not affect the values of TAS, SOD and GR in the vitreous fluid. The duration of the disease influences TAS in the vitreous in eyes with RRD complicated with PVR.
(1) 背景：本研究的目的是检验以下假设：因孔源性视网膜脱离（RRD）伴或不伴增殖性玻璃体视网膜病变（PVR）而接受玻璃体切割术的患眼玻璃体中的抗氧化状态高于因其他视网膜疾病而接受玻璃体切割术的患眼。(2) 方法：分析了四组患者：22例无PVR的RRD患者的患眼、27例有RRD和PVR的患眼、22例黄斑裂孔（MH）患者的患眼和10例视网膜前膜（ERM）患者的患眼。采用分光光度法测定玻璃体液样本中的总抗氧化状态（TAS）值以及超氧化物歧化酶（SOD）和谷胱甘肽还原酶（GR）活性。(3) 结果：在有和无PVR的RRD患者以及有MH和ERM的患者中，未观察到TAS值和抗氧化酶活性有显著差异。导致PVR的RRD持续时间越长且术后视力越好，TAS水平越高。在RRD组和RRD合并PVR组的“黄斑在位”和“黄斑脱离”亚组之间未发现显著差异。(4) 结论：初步结果不支持以下论点：与MH和ERM患者相比，RRD伴或不伴PVR患者接受玻璃体切割术后的抗氧化状态存在差异。在RRD患者中，PVR的存在和黄斑脱离不影响玻璃体中TAS、SOD和GR的值。疾病持续时间影响合并PVR的RRD患眼玻璃体中的TAS。
