Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L3N6, Canada.
Cells. 2021 May 19;10(5):1252. doi: 10.3390/cells10051252.
Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated. This review discusses receptor glycosylation and the known roles of glycans on the functions of receptors expressed in diverse cell types. We included growth factor receptors that have an intracellular tyrosine kinase domain, growth factor receptors that have a serine/threonine kinase domain, and cell-death-inducing receptors. - and -glycans have a wide range of functions including roles in receptor conformation, ligand binding, oligomerization, and activation of signaling cascades. A better understanding of these functions will enable control of cell survival and cell death in diseases such as cancer and in immune responses.
细胞通过多种细胞表面受体经历增殖和凋亡、迁移和分化，其中大多数受体都高度糖基化。本综述讨论了受体糖基化以及糖基在不同细胞类型中表达的受体功能中的已知作用。我们包括具有细胞内酪氨酸激酶结构域的生长因子受体、具有丝氨酸/苏氨酸激酶结构域的生长因子受体和细胞死亡诱导受体。- 和 -聚糖具有广泛的功能，包括在受体构象、配体结合、寡聚化和信号级联激活中发挥作用。更好地了解这些功能将能够控制癌症等疾病和免疫反应中的细胞存活和细胞死亡。
