Electronic and Microelectronics Lab, Department of Physics, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia.
Department of Physics, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Sensors (Basel). 2021 May 18;21(10):3502. doi: 10.3390/s21103502.
The objective of the current study is to analyze numerically the effect of the temperature-jump boundary condition on heterogeneous microfluidic immunosensors under electrothermal force. A three-dimensional simulation using the finite element method on the binding reaction kinetics of C-reactive protein (CRP) was performed. The kinetic reaction rate was calculated with coupled Laplace, Navier-Stokes, energy, and mass diffusion equations. Two types of reaction surfaces were studied: one in the form of a disc surrounded by two electrodes and the other in the form of a circular ring, one electrode is located inside the ring and the other outside. The numerical results reveal that the performance of a microfluidic biosensor is enhanced by using the second design of the sensing area (circular ring) coupled with the electrothermal force. The improvement factor under the applied ac field 15 V was about 1.2 for the first geometry and 3.6 for the second geometry. Furthermore, the effect of temperature jump on heat transfer rise and response time was studied. The effect of two crucial parameters, viz. Knudsen number (Kn) and thermal accommodation coefficient () with and without electrothermal effect, were analyzed for the two configurations.
本研究的目的是分析温度跳跃边界条件对电热力作用下非均相微流控免疫传感器的影响。使用有限元方法对 C 反应蛋白 (CRP) 的结合反应动力学进行了三维模拟。通过耦合拉普拉斯方程、纳维-斯托克斯方程、能量方程和质量扩散方程计算了动力学反应速率。研究了两种反应表面：一种是被两个电极包围的圆盘形式，另一种是圆形环的形式，一个电极位于环内，另一个电极位于环外。数值结果表明，通过使用带有电热力的第二种传感区域（圆形环）设计，可以增强微流控生物传感器的性能。在施加的交流场 15 V 下，第一种几何形状的改进因子约为 1.2，第二种几何形状的改进因子约为 3.6。此外，还研究了温度跳跃对传热上升和响应时间的影响。分析了两个关键参数，即克努森数 (Kn) 和热配位数 ()，在有无电热效应的情况下对两种配置的影响。
