State Key Laboratory of Remote Sensing Science, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China.
Guangxi Key Laboratory of Spatial Information and Geomatics, Guilin University of Technology, Guilin 541004, China.
Int J Environ Res Public Health. 2021 May 18;18(10):5353. doi: 10.3390/ijerph18105353.
Exposure to air pollution has been suggested to be associated with an increased risk of women's health disorders. However, it remains unknown to what extent changes in ambient air pollution affect gynecological cancer. In our case-control study, the logistic regression model was combined with the restricted cubic spline to examine the association of short-term exposure to air pollution with gynecological cancer events using the clinical data of 35,989 women in Beijing from December 2008 to December 2017. We assessed the women's exposure to air pollutants using the monitor located nearest to each woman's residence and working places, adjusting for age, occupation, ambient temperature, and ambient humidity. The adjusted odds ratios (ORs) were examined to evaluate gynecologic cancer risk in six time windows (Phase 1-Phase 6) of women's exposure to air pollutants (PM, CO, O, and SO) and the highest ORs were found in Phase 4 (240 days). Then, the higher adjusted ORs were found associated with the increased concentrations of each pollutant (PM, CO, O, and SO) in Phase 4. For instance, the adjusted OR of gynecological cancer risk for a 1.0-mg m increase in CO exposures was 1.010 (95% CI: 0.881-1.139) below 0.8 mg m, 1.032 (95% CI: 0.871-1.194) at 0.8-1.0 mg m, 1.059 (95% CI: 0.973-1.145) at 1.0-1.4 mg m, and 1.120 (95% CI: 0.993-1.246) above 1.4 mg m. The ORs calculated in different air pollution levels accessed us to identify the nonlinear association between women's exposure to air pollutants (PM, CO, O, and SO) and the gynecological cancer risk. This study supports that the gynecologic risks associated with air pollution should be considered in improved public health preventive measures and policymaking to minimize the dangerous effects of air pollution.
空气污染暴露与女性健康问题的风险增加有关。然而，目前尚不清楚环境空气污染的变化在多大程度上影响妇科癌症。在我们的病例对照研究中，使用 2008 年 12 月至 2017 年 12 月北京 35989 名女性的临床数据，结合逻辑回归模型和限制立方样条，研究了短期暴露于空气污染物与妇科癌症事件之间的关联。我们使用位于每个女性居住地和工作地最近的监测器评估女性暴露于空气污染物的情况，同时调整年龄、职业、环境温度和环境湿度。评估了 6 个时间窗（第 1 期至第 6 期）中女性暴露于空气污染物（PM、CO、O 和 SO）的调整后比值比（OR），发现第 4 期（240 天）的妇科癌症风险最高。然后，发现与第 4 期每种污染物（PM、CO、O 和 SO）浓度增加相关的调整后更高的 OR。例如，CO 暴露每增加 1.0mg/m，妇科癌症风险的调整 OR 为 1.010（95%CI：0.881-1.139），低于 0.8mg/m 时为 1.032（95%CI：0.871-1.194），在 0.8-1.0mg/m 时为 1.059（95%CI：0.973-1.145），在 1.0-1.4mg/m 时为 1.120（95%CI：0.993-1.246），高于 1.4mg/m 时为 1.120（95%CI：0.993-1.246）。在不同的空气污染水平下计算的 OR 使我们能够识别女性暴露于空气污染物（PM、CO、O 和 SO）与妇科癌症风险之间的非线性关联。这项研究支持在改善公共卫生预防措施和决策中考虑与空气污染相关的妇科风险，以最小化空气污染的危险影响。
