Korsakov Anton V, Golovleva Alexandra A, Troshin Vladislav P, Lagerev Dmitry G, Pugach Leonid I
Laboratory "Human Ecology and Data Analysis in the Technosphere", Bryansk State Technical University, 241035 Bryansk, Russia.
Life (Basel). 2021 Nov 21;11(11):1272. doi: 10.3390/life11111272.
Radioactive contamination and chemical pollution of the environment can affect the processes of carcinogenesis, including the formation of malignant neoplasms of the ovaries in women. We used the data of official state statistics for 2000-2020 to test the hypothesis about the effect of radioactive contamination (following the Chernobyl disaster) and chemical pollutants on the incidence of ovarian malignancies in the female population of the Bryansk region. A variety of statistical approaches were used to estimate the incidence of ovarian malignancies, including the Shapiro-Wilk test, Mann-Whitney U test, Spearman's rank correlation test and linear regression. We did not establish statistically significant differences in the frequency of primary morbidity of women with malignant neoplasms of the ovaries, regardless of the environmental conditions of living. Furthermore, no significant correlations were found between the frequency of primary morbidity of ovarian malignancies, both with the level of contamination by Cesium-137 and Strontium-90, and air pollution with volatile organic compounds, carbon monoxide, sulfur dioxide and nitrogen oxides. A statistically significant increase in the long-term trend in the frequency of ovarian malignant neoplasms was revealed in the areas of chemical pollution ( = 0.02), however, in other territories, no statistically significant regularities were established. The forecast of the frequency of newly diagnosed malignant neoplasms of the ovaries on average in the Bryansk region shows an increase of 12.4% in 2020 in comparison with the real data for 2020, while the largest increase in predicted values is recorded in the territories of radioactive contamination (by 79.6%), and the least in the combined territories (by 6.9%). The results obtained indicate the need for further work to understand the trends in the presence/absence of independent and combined effects of pollutants and the growth of oncogynecological pathology from the perspective of assessing the distant and regional metastasis, histological and immunohistochemical profile of a specific malignant ovarian neoplasm with levels of environmental contamination.
环境的放射性污染和化学污染会影响致癌过程，包括女性卵巢恶性肿瘤的形成。我们利用2000 - 2020年国家官方统计数据，来检验关于放射性污染（切尔诺贝利灾难之后）和化学污染物对布良斯克地区女性人群卵巢恶性肿瘤发病率影响的假设。我们采用了多种统计方法来估计卵巢恶性肿瘤的发病率，包括夏皮罗-威尔克检验、曼-惠特尼U检验、斯皮尔曼等级相关检验和线性回归。无论生活的环境条件如何，我们都未发现卵巢恶性肿瘤女性原发性发病率在频率上存在统计学显著差异。此外，卵巢恶性肿瘤原发性发病率频率与铯-137和锶-90的污染水平以及挥发性有机化合物、一氧化碳、二氧化硫和氮氧化物的空气污染之间均未发现显著相关性。在化学污染地区，卵巢恶性肿瘤频率的长期趋势显示出统计学显著增加（ = 0.02），然而，在其他地区，未发现统计学显著规律。布良斯克地区平均新诊断卵巢恶性肿瘤频率的预测显示，与2020年的实际数据相比，2020年增加了12.4%，而预测值增加最大的是在放射性污染地区（增加79.6%），最小的是在综合地区（增加6.9%）。所得结果表明，需要进一步开展工作，从评估环境污染水平下特定卵巢恶性肿瘤的远处和区域转移、组织学和免疫组化特征的角度，了解污染物独立和联合效应的存在与否趋势以及肿瘤妇科病理学的增长情况。
