Bae Joon-Yong, Kim Jin Il, Park Mee Sook, Lee Gee Eun, Park Heedo, Song Ki-Joon, Park Man-Seong
Department of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of Medicine, Seoul 02841, Korea.
Vaccines (Basel). 2021 May 18;9(5):518. doi: 10.3390/vaccines9050518.
Zoonotic transmission of from rodent reservoirs to humans has been the cause of severe fatalities. Human infections are reported worldwide, but vaccines have been approved only in China and Korea. vaccine development has been pursued with no sense of urgency due to the relative paucity of cases in countries outside China and Korea. However, the continuously evolve in hosts and thus the current vaccine may not work as well against some variants. Therefore, a more effective vaccine should be prepared against the . In this review, we discuss the issues caused by the vaccine. Given the pros and cons of the vaccine, we suggest strategies for the development of better vaccines in terms of pandemic preparedness.
从啮齿类动物宿主向人类的人畜共患传播一直是严重致死事件的原因。全球都有人类感染的报告，但疫苗仅在中国和韩国获得批准。由于中国和韩国以外的国家病例相对较少，疫苗研发一直没有紧迫感。然而，（病原体）在宿主中不断进化，因此目前的疫苗可能对某些变体效果不佳。所以，应该制备一种针对（该病原体）更有效的疫苗。在本综述中，我们讨论了（该病原体）疫苗引发的问题。鉴于（该病原体）疫苗的利弊，我们就大流行防范提出了开发更好疫苗的策略。
