Amaral Carolina Dourado, Costa Galileu Barbosa, de Souza William Marciel, Alves Pedro Augusto, Borges Iara Apolinário, Tolardo Aline Lavado, Romeiro Marília Farignoli, Drumond Betânia Paiva, Abrahão Jônatas Santos, Kroon Erna Geessien, Paglia Adriano Pereira, Figueiredo Luiz Tadeu Moraes, de Souza Trindade Giliane
Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627 - Campus Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Ecohealth. 2018 Sep;15(3):577-589. doi: 10.1007/s10393-018-1353-2. Epub 2018 Aug 13.
New World orthohantaviruses are emerging RNA viruses that cause hantavirus cardiopulmonary syndrome (HCPS). These viruses are a burden to public health around the world with a lethality rate of around 60%. In South America, rodents of Sigmodontinae subfamily are the main reservoirs of orthohantaviruses. We described a serosurvey for orthohantaviruses circulation in an apparently healthy human population and small mammals from rural areas in Central Minas Gerais State, Brazil. A total of 240 individuals and 50 small mammals (26 rodents belonging to 10 different species and 24 marsupials from 4 different species) were sampled during 2012-2013. The seroprevalence rates of IgG/IgM antibodies in humans were 7.1 and 1.6%, respectively. Only one rodent, an Oligoryzomys nigripes captured in peridomestic area, tested positive for IgG antibodies and viral RNA. Our findings suggest a silent circulation of orthohantaviruses in a region of intensive agriculture production. The detection of seropositive humans in an area with a lack of previous HCPS reports highlights potential oligosymptomatic cases and the need for surveillance strategies that could reduce the risk of future outbreaks.
新大陆汉坦病毒是一类新兴的RNA病毒，可引发汉坦病毒心肺综合征（HCPS）。这些病毒对全球公共卫生构成负担，致死率约为60%。在南美洲，稻鼠亚科啮齿动物是汉坦病毒的主要宿主。我们描述了一项针对巴西米纳斯吉拉斯州中部农村地区看似健康的人群和小型哺乳动物中汉坦病毒传播情况的血清学调查。在2012年至2013年期间，共采集了240名个体和50只小型哺乳动物（26只属于10个不同物种的啮齿动物和24只来自4个不同物种的有袋动物）的样本。人类中IgG/IgM抗体的血清阳性率分别为7.1%和1.6%。仅一只在住宅周边区域捕获的黑稻鼠，其IgG抗体和病毒RNA检测呈阳性。我们的研究结果表明，在一个集约化农业生产地区，汉坦病毒在悄然传播。在一个此前缺乏HCPS报告的地区检测到血清阳性的人类，凸显了潜在的轻症病例以及采取监测策略以降低未来疫情爆发风险的必要性。
