Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA.
Department of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA.
Viruses. 2021 May 25;13(6):980. doi: 10.3390/v13060980.
SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. To this end, we evaluated a new class of organometallic complexes as potential antivirals. Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool complexes, CpRh(1,3-dicyclohexylimidazol-2-ylidene)Cl (complex 2) and CpRh(dipivaloylmethanato)Cl (complex 4), have direct virucidal activity against SARS-CoV-2. Subsequent in vitro testing suggests that complex 4 is the more stable and effective complex and demonstrates that both 2 and 4 have low toxicity in Vero E6 and Calu-3 cells. The results presented here highlight the potential application of organometallic complexes as antivirals and support further investigation into their activity.
SARS-CoV-2 于 2019 年出现，是一种具有破坏性的病毒病原体，目前尚无预防或治疗方法来控制这种病毒，导致了当前的全球大流行。病毒的持续传播和死亡人数的不断增加，需要开发有效的抗病毒治疗方法来对抗这种病毒。为此，我们评估了一类新的有机金属配合物作为潜在的抗病毒药物。我们的研究结果表明，两种五甲基环戊二烯基（Cp*）铑钢琴凳配合物，CpRh（1,3-二环己基咪唑-2-亚基）Cl（配合物 2）和 CpRh（二（戊酰基）甲叉）Cl（配合物 4），对 SARS-CoV-2 具有直接的病毒杀灭活性。随后的体外测试表明，配合物 4 是更稳定和有效的配合物，并且证明 2 和 4 在 Vero E6 和 Calu-3 细胞中均具有低毒性。这里提出的结果强调了有机金属配合物作为抗病毒药物的潜在应用，并支持进一步研究其活性。
