Kelly Liam P, Devasahayam Augustine J, Chaves Arthur R, Curtis Marie E, Randell Edward W, McCarthy Jason, Basset Fabien A, Ploughman Michelle
Recovery and Performance Laboratory, L.A. Miller Centre, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL A1K 5A1, Canada.
School of Human Kinetics and Recreation, Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.
J Clin Med. 2021 May 30;10(11):2423. doi: 10.3390/jcm10112423.
Moderate-intensity aerobic exercise training is an important treatment strategy to enhance functional recovery and decrease cardiometabolic risk factors after stroke. However, stroke related impairments limit access to ergometer-type exercise. The aims of the current study were (1) to evaluate whether our task-oriented circuit training protocol (intermittent functional training; IFT) could be used to sustain moderate-intensity aerobic workloads over a 10-week intervention period, and (2) to investigate its preliminary effects on cardiorespiratory fitness and metabolic profiles compared to constant-load ergometer-type exercise (CET). Forty chronic hemiparetic stroke survivors were randomized to receive 30 sessions of IFT or CET over ten weeks. Similar proportions of participants were randomized to IFT (7/19) and CET (9/18) sustained workloads associated with moderate-intensity aerobic exercise over the study period ( = 0.515). However, CET was associated with more substantial changes in maximal oxygen uptake (MD = 2.79 mL min kg CI: 0.84 to 4.74) compared to IFT (MD = 0.62 mL min kg CI: -0.38 to 1.62). Pre to post changes in C-reactive protein (-0.9 mg/L; =0.017), short-term glycemia (+14.7 mol/L; = 0.026), and resting whole-body carbohydrate oxidation (+24.2 mg min; = 0.046) were observed when considering both groups together. Accordingly, IFT can replicate the aerobic intensities sustained during traditional ergometer-type exercise training. More work is needed to evaluate the dose-response effects of such task-oriented circuit training protocols on secondary prevention targets across the continuum of stroke recovery.
中等强度有氧运动训练是促进中风后功能恢复和降低心血管代谢危险因素的重要治疗策略。然而，与中风相关的功能障碍限制了使用测力计式运动。本研究的目的是：（1）评估我们的任务导向循环训练方案（间歇性功能训练；IFT）是否可用于在10周的干预期内维持中等强度的有氧工作量；（2）与恒定负荷测力计式运动（CET）相比，研究其对心肺适能和代谢状况的初步影响。40名慢性偏瘫中风幸存者被随机分配，在十周内接受30次IFT或CET训练。在研究期间，相似比例的参与者被随机分配到IFT组（7/19）和CET组（9/18），维持与中等强度有氧运动相关的工作量（P = 0.515）。然而，与IFT（MD = 0.62 mL·min−1·kg−1；95%CI：-0.38至1.62）相比，CET与最大摄氧量的更大变化相关（MD = 2.79 mL·min−1·kg−1；95%CI：0.84至4.74）。将两组一起考虑时，观察到C反应蛋白的前后变化（-0.9 mg/L；P = 0.017）、短期血糖（+14.7 μmol/L；P = 0.026）和静息全身碳水化合物氧化（+24.2 mg·min−1；P = 0.046）。因此，IFT可以复制传统测力计式运动训练中维持的有氧强度。需要更多的研究来评估这种任务导向循环训练方案对中风恢复连续过程中二级预防目标的剂量反应效应。
