Baratto Lucia, Toriihara Akira, Hatami Negin, Aparici Carina M, Davidzon Guido, Levin Craig S, Iagaru Andrei
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, CA 94035, USA.
PET Imaging Center, Asahi General Hospital, Asahi 289-1101, Japan.
Diagnostics (Basel). 2021 May 30;11(6):992. doi: 10.3390/diagnostics11060992.
We prospectively enrolled patients with neuroendocrine tumors (NETs). They underwent a single Ga-DOTA-TATE injection followed by dual imaging and were randomly scanned using first either the conventional or the silicon photomultiplier (SiPM) positron emission tomography/computed tomography (PET/CT), followed by imaging using the other system. A total of 94 patients, 44 men and 50 women, between 35 and 91 years old (mean ± SD: 63 ± 11.2), were enrolled. Fifty-two out of ninety-four participants underwent SiPM PET/CT first and a total of 162 lesions were detected using both scanners. Forty-two out of ninety-four participants underwent conventional PET/CT first and a total of 108 lesions were detected using both scanners. Regardless of whether SiPM-based PET/CT was used first or second, maximum standardized uptake value (SUV) of lesions measured on SiPM was on average 20% higher when comparing two scanners with all enrolled patients, and the difference was statistically significant. SiPM-based PET/CT detected 19 more lesions in 13 patients compared with conventional PET/CT. No lesions were only identified by conventional PET/CT. In conclusion, we observed higher SUV for lesions measured from SiPM PET/CT compared with conventional PET/CT regardless of the order of the scans. SiPM PET/CT allowed for identification of more lesions than conventional PET/CT. While delayed imaging can lead to higher SUV in cancer lesions, in the series of lesions identified when SiPM PET/CT was used first, this was not the case; therefore, the data suggest superior performance of the SiPM PET/CT scanner in visualizing and quantifying lesions.
我们前瞻性地纳入了神经内分泌肿瘤（NETs）患者。他们接受了单次Ga-DOTA-TATE注射，随后进行双模态成像，并随机先使用传统型或硅光电倍增管（SiPM）正电子发射断层扫描/计算机断层扫描（PET/CT）进行扫描，然后再使用另一系统进行成像。共纳入了94例患者，其中男性44例，女性50例，年龄在35至91岁之间（平均±标准差：63±11.2）。94名参与者中有52名先接受了SiPM PET/CT检查，两台扫描仪共检测到162个病灶。94名参与者中有42名先接受了传统PET/CT检查，两台扫描仪共检测到108个病灶。无论基于SiPM的PET/CT是先使用还是后使用，在对所有纳入患者的两台扫描仪进行比较时，SiPM上测量的病灶最大标准化摄取值（SUV）平均高20%，且差异具有统计学意义。与传统PET/CT相比，基于SiPM的PET/CT在13例患者中多检测到19个病灶。没有病灶仅由传统PET/CT识别出来。总之，无论扫描顺序如何，我们观察到与传统PET/CT相比，SiPM PET/CT测量的病灶SUV更高。SiPM PET/CT比传统PET/CT能识别更多的病灶。虽然延迟成像可导致癌症病灶的SUV升高，但在首次使用SiPM PET/CT时识别出的一系列病灶中并非如此；因此，数据表明SiPM PET/CT扫描仪在病灶可视化和定量方面具有更优的性能。
