Department of Radiology, Fukuoka Memorial PET Imaging and Medical Checkup Center.
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University.
Nucl Med Commun. 2021 Dec 1;42(12):1361-1368. doi: 10.1097/MNM.0000000000001468.
To clarify differences in arterial 18F-FDG (fluorodeoxyglucose) uptake between silicon photomultiplier (SiPM)-based and conventional PET/CT scanners, and to compare clinical and phantom results.
Twenty-six patients with lung tumours underwent serial SiPM-based and conventional PET/CT scans on the same day. We compared the target-to-background ratios [TBRsi (SiPM), TBRc (conventional)] and the percentage difference between TBRsi and TBRc (ΔTBR) in the carotid artery, aorta and peripheral arteries. The correlation between ΔTBR and vessel size was also investigated. In the carotid artery, active segment analyses were performed with the threshold (TBR ≥1.6), and we compared each scanner's ratio of active segments and TBR values. We compared the clinical results with the recovery coefficients (RCs).
The TBRsi was significantly higher than the TBRc in the carotid artery, aorta and peripheral arteries (1.63 ± 0.22 vs. 1.43 ± 0.22, 1.65 ± 0.19 vs. 1.53 ± 0.15 and 1.37 ± 0.31 vs. 1.11 ± 0.27, mean ± SD, P ≤ 0.0001 for all), and the peripheral arteries showed the highest ΔTBR (24.4 ± 16.8%). The small (10-15 mm) vessels (26.9 ± 15.9%) showed significantly higher ΔTBRs than the larger vessels (7.3 ± 8.5% for 15-20 mm, 8.0 ± 12.8% for ≥20 mm, P < 0.0001 for both). The carotid artery showed significantly higher ratios of active segment (54.5 vs. 20.5%, P < 0.0001) and TBR values (1.85 ± 0.25 vs. 1.76 ± 0.15, P = 0.0006) for TBRsi vs. TBRc. The differences in RCs were similar to those of ΔTBR for each vessel size.
SiPM-based PET/CT scanners showed higher arterial 18F-FDG uptake (especially in vessels <15 mm) than conventional scanners, and the threshold TBR ≥1.6 is not applicable for the carotid artery for SiPM-based PET/CT systems.
阐明基于硅光电倍增管（SiPM）的 PET/CT 与传统 PET/CT 扫描仪之间动脉 18F-FDG（氟代脱氧葡萄糖）摄取的差异，并比较临床和体模结果。
26 例肺部肿瘤患者于同一天进行基于 SiPM 的和传统的 PET/CT 扫描。我们比较了颈动脉、主动脉和外周动脉的靶与背景比[TBRsi（SiPM）、TBRc（传统）]和 TBRsi 与 TBRc 之间的差异百分比（ΔTBR）。还研究了ΔTBR 与血管大小之间的相关性。在颈动脉中，使用阈值（TBR≥1.6）进行了活性段分析，并比较了每个扫描仪的活性段比例和 TBR 值。我们将临床结果与恢复系数（RC）进行了比较。
在颈动脉、主动脉和外周动脉中，TBRsi 明显高于 TBRc（1.63±0.22 比 1.43±0.22，1.65±0.19 比 1.53±0.15，1.37±0.31 比 1.11±0.27，均值±SD，P≤0.0001 均为所有），并且外周动脉显示出最高的ΔTBR（24.4±16.8%）。小（10-15mm）血管（26.9±15.9%）的ΔTBR 明显高于大血管（15-20mm 为 7.3±8.5%，≥20mm 为 8.0±12.8%，P≤0.0001 均为所有）。颈动脉显示出活性段（54.5%比 20.5%，P<0.0001）和 TBR 值（1.85±0.25 比 1.76±0.15，P=0.0006）的 TBRsi 与 TBRc 的比值明显更高。各血管大小的 RC 差异与ΔTBR 相似。
基于 SiPM 的 PET/CT 扫描仪比传统扫描仪显示出更高的动脉 18F-FDG 摄取（尤其是在<15mm 的血管中），并且对于基于 SiPM 的 PET/CT 系统，阈值 TBR≥1.6 不适用于颈动脉。
