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CXCL12轴在结直肠癌肺转移中的作用

The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer.

作者信息

Wang Meng, Yang Xuyang, Wei Mingtian, Wang Ziqiang

机构信息

Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, 610041.

出版信息

J Cancer. 2018 Oct 10;9(21):3898-3903. doi: 10.7150/jca.26383. eCollection 2018.

DOI:10.7150/jca.26383
PMID:30410593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6218771/
Abstract

This study aimed to explore the mechanism of lung metastases of colorectal cancer. The expression of CXCR4, CXCR7, and CXCL12 in colorectal cancer and lung metastases was analyzed by the immunohistochemical (IHC) method. Further, the study aimed at getting new insights into the role of CXCL12 in lung metastasis. A total of 41 patients who underwent surgical resections for both colorectal cancer and lung metastasis were retrospectively selected for this study. Also, 41 patients who underwent lung resection for benign lung disease were selected as the control group. In the experiment, the mice were injected with exosomes isolated from CT26. The mice with and without injection were sacrificed 3 weeks later. The lung tissue was analyzed by the IHC method and quantitative real-time PCR. The expression of CXCR7 and CXCL12 was significantly higher in lung metastases than in paired primary lesions. The expression of CXCL12 was significantly higher in the noncancerous lung tissue of patients with CRC than in patients with benign lung disease. Also, the expression of CXCL12 in the lung was higher in mice with exosome education. The results inferred that the expression of CXCR7 and CXCL12 was significantly higher in lung metastases than in primary tumors. Their combination could promote colorectal cancer lung metastasis. The expression of CXCL12 was elevated before metastasis. And this effect was induced by exosomes.

摘要

本研究旨在探讨结直肠癌肺转移的机制。采用免疫组织化学（IHC）方法分析CXCR4、CXCR7和CXCL12在结直肠癌及肺转移灶中的表达。此外，本研究旨在深入了解CXCL12在肺转移中的作用。本研究回顾性选取了41例行结直肠癌及肺转移灶手术切除的患者。同时，选取41例行肺良性疾病肺切除术的患者作为对照组。在实验中，给小鼠注射从CT26分离的外泌体。3周后处死注射和未注射的小鼠。采用免疫组织化学方法和定量实时PCR分析肺组织。CXCR7和CXCL12在肺转移灶中的表达明显高于配对的原发灶。CXCL12在结直肠癌患者的非癌性肺组织中的表达明显高于良性肺疾病患者。此外，接受外泌体处理的小鼠肺中CXCL12的表达更高。结果推断，CXCR7和CXCL12在肺转移灶中的表达明显高于原发肿瘤。它们的联合作用可促进结直肠癌肺转移。CXCL12的表达在转移前升高。且这种作用是由外泌体诱导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/838d73f7352c/jcav09p3898g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/b009221a5f28/jcav09p3898g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/7518860075c3/jcav09p3898g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/19ac04c6686e/jcav09p3898g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/d82b6ac43fbb/jcav09p3898g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/838d73f7352c/jcav09p3898g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/b009221a5f28/jcav09p3898g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/7518860075c3/jcav09p3898g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/19ac04c6686e/jcav09p3898g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/d82b6ac43fbb/jcav09p3898g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a8/6218771/838d73f7352c/jcav09p3898g005.jpg

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