EA 3842-CAPTuR, GEIST Institute, Faculty of Medicine, University of Limoges, 2 rue du Dr Marcland, CEDEX, 87025 Limoges, France.
Cells. 2021 May 27;10(6):1330. doi: 10.3390/cells10061330.
Even though cancers have been widely studied and real advances in therapeutic care have been made in the last few decades, relapses are still frequently observed, often due to therapeutic resistance. Cancer Stem Cells (CSCs) are, in part, responsible for this resistance. They are able to survive harsh conditions such as hypoxia or nutrient deprivation. Autophagy and Extracellular Vesicles (EVs) secretion are cellular processes that help CSC survival. Autophagy is a recycling process and EVs secretion is essential for cell-to-cell communication. Their roles in stemness maintenance have been well described. A common pathway involved in these processes is vesicular trafficking, and subsequently, regulation by Rab GTPases. In this review, we analyze the role played by Rab GTPases in stemness status, either directly or through their regulation of autophagy and EVs secretion.
尽管癌症已经得到广泛研究，并且在过去几十年中在治疗护理方面取得了真正的进展，但复发仍然经常发生，这主要是由于治疗耐药性。癌症干细胞（CSC）在一定程度上对此耐药性负责。它们能够在缺氧或营养缺乏等恶劣条件下存活。自噬和细胞外囊泡（EVs）的分泌是有助于 CSC 存活的细胞过程。自噬是一种回收过程，EVs 的分泌对于细胞间通讯至关重要。它们在维持干细胞特性方面的作用已得到充分描述。涉及这些过程的共同途径是囊泡运输，随后是 Rab GTPases 的调节。在这篇综述中，我们分析了 Rab GTPases 通过直接或通过调节自噬和 EVs 分泌在干细胞状态中的作用。
