Gracia-Rubio Irene, Martín César, Civeira Fernando, Cenarro Ana
Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain.
Instituto Biofisika (UPV/EHU, CSIC) y Departamento de Bioquímica y Biología Molecular, Universidad del País Vasco UPB/EHU, 48940 Bilbao, Spain.
Biomedicines. 2021 May 27;9(6):612. doi: 10.3390/biomedicines9060612.
High plasma level of low-density lipoprotein (LDL) is the main driver of the initiation and progression of cardiovascular disease (CVD). Nevertheless, high-density lipoprotein (HDL) is considered an anti-atherogenic lipoprotein due to its role in reverse cholesterol transport and its ability to receive cholesterol that effluxes from macrophages in the artery wall. The scavenger receptor B class type 1 (SR-B1) was identified as the high-affinity HDL receptor, which facilitates the selective uptake of cholesterol ester (CE) into the liver via HDL and is also implicated in the plasma clearance of LDL, very low-density lipoprotein (VLDL) and lipoprotein(a) (Lp(a)). Thus, SR-B1 is a multifunctional receptor that plays a main role in the metabolism of different lipoproteins. The aim of this review is to highlight the association between SR-B1 and CVD risk through mice and human genetic studies.
低密度脂蛋白（LDL）的高血浆水平是心血管疾病（CVD）发生和发展的主要驱动因素。然而，高密度脂蛋白（HDL）因其在逆向胆固醇转运中的作用以及接收从动脉壁巨噬细胞流出的胆固醇的能力，被认为是一种抗动脉粥样硬化脂蛋白。1类清道夫受体B（SR-B1）被确定为高亲和力HDL受体，它促进胆固醇酯（CE）通过HDL选择性摄取到肝脏中，并且还参与LDL、极低密度脂蛋白（VLDL）和脂蛋白（a）[Lp（a）]的血浆清除。因此，SR-B1是一种多功能受体，在不同脂蛋白的代谢中起主要作用。本综述的目的是通过小鼠和人类遗传学研究强调SR-B1与CVD风险之间的关联。
