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利什曼原虫活性及有效成分对抗.

L.: Antitrypanosomal Activity and Active Constituents against .

机构信息

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus, Corrensstr. 48, D-48149 Münster, Germany.

Swiss Tropical and Public Health Institute (Swiss TPH), Socinstrasse 57, CH-4051 Basel, Switzerland.

出版信息

Molecules. 2021 May 27;26(11):3226. doi: 10.3390/molecules26113226.

DOI:10.3390/molecules26113226
PMID:34072147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8199030/
Abstract

As part of our studies on antiprotozoal activity of approved herbal medicinal products, we previously found that a commercial tincture from L. (common Sage, Lamiaceae) possesses high activity against , causative agent of East African Human Trypanosomiasis. We have now investigated in detail the antitrypanosomal constituents of this preparation. A variety of fractions were tested for antitrypanosomal activity and analyzed by UHPLC/+ESI QqTOF MS. The resulting data were used to generate a partial least squares (PLS) regression model that highlighted eight particular constituents that were likely to account for the major part of the bioactivity. These compounds were then purified and identified and their activity against the pathogen tested. All identified compounds (one flavonoid and eight diterpenes) displayed significant activity against , in some cases higher than that of the total tincture. From the overall results, it can be concluded that the antitrypanosomal activity of L. is, for the major part, caused by abietane-type diterpenes of the rosmanol/rosmaquinone group.

摘要

作为我们对已批准草药抗原生动物活性研究的一部分，我们之前发现一种来自 L.（普通鼠尾草，唇形科）的商业酊剂对 具有高活性， 是东非人类锥虫病的病原体。我们现在已经详细研究了该制剂的抗锥虫成分。测试了多种馏分的抗锥虫活性，并通过 UHPLC/+ESI QqTOF MS 进行分析。所得数据用于生成偏最小二乘（PLS）回归模型，突出了可能占大部分生物活性的八个特定成分。然后对这些化合物进行了纯化和鉴定，并测试了它们对病原体的活性。所有鉴定的化合物（一种类黄酮和八种二萜）对 均显示出显著的活性，在某些情况下高于总酊剂的活性。从整体结果可以得出结论， L. 的抗锥虫活性主要是由罗莎醇/罗莎醌组的土木香烷型二萜引起的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd38/8199030/3682d6dcec21/molecules-26-03226-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd38/8199030/fd3c90c0efb1/molecules-26-03226-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd38/8199030/06bc9e4ab380/molecules-26-03226-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd38/8199030/3682d6dcec21/molecules-26-03226-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd38/8199030/fd3c90c0efb1/molecules-26-03226-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd38/8199030/06bc9e4ab380/molecules-26-03226-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd38/8199030/3682d6dcec21/molecules-26-03226-g003.jpg

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本文引用的文献

1
Structure-Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents.肉桂酸酯类似物作为有效抗寄生虫药物的构效关系。
ChemMedChem. 2020 Jan 7;15(1):68-78. doi: 10.1002/cmdc.201900544. Epub 2019 Nov 12.
2
Oral fexinidazole for human African trypanosomiasis.口服非昔硝唑治疗人类非洲锥虫病。
Lancet. 2018 Jan 13;391(10116):100-102. doi: 10.1016/S0140-6736(18)30019-9.
3
Salvia Species as Sources of Natural Products with Antiprotozoal Activity.唇形科鼠尾草属植物作为具有抗原生动物活性天然产物的来源。
基于偏最小二乘预测从 L. 中鉴定抗原虫化合物。
Molecules. 2021 Oct 13;26(20):6181. doi: 10.3390/molecules26206181.
Int J Mol Sci. 2018 Jan 16;19(1):264. doi: 10.3390/ijms19010264.
4
Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases.寻找草药制剂中的抗原生动物活性；对抗被忽视热带病的新天然先导物。
Molecules. 2015 Aug 4;20(8):14118-38. doi: 10.3390/molecules200814118.
5
Constituents from Salvia species and their biological activities.鼠尾草属植物的成分及其生物活性。
Chem Rev. 2012 Nov 14;112(11):5967-6026. doi: 10.1021/cr200058f. Epub 2012 Sep 11.
6
Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from Salvia miltiorrhiza.丹参酮型二萜类化合物的抗疟原虫和抗锥虫活性。
Planta Med. 2011 Sep;77(14):1594-6. doi: 10.1055/s-0030-1270933. Epub 2011 Mar 16.
7
Variations in essential oil, phenolic compounds, and antioxidant activity of tunisian cultivated Salvia officinalis L.突尼斯栽培的药用鼠尾草 Salvia officinalis L. 的精油、酚类化合物和抗氧化活性的变化
J Agric Food Chem. 2009 Nov 11;57(21):10349-56. doi: 10.1021/jf901877x.
8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.枞酸型二萜的半合成及生物学评价。迷迭香醌结构的修正。
J Nat Prod. 2009 Aug;72(8):1385-9. doi: 10.1021/np900047p.
9
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies.黄酮类化合物及其类似物的抗锥虫和抗利什曼原虫活性：体外、体内、构效关系和定量构效关系研究
Antimicrob Agents Chemother. 2006 Apr;50(4):1352-64. doi: 10.1128/AAC.50.4.1352-1364.2006.
10
Semisynthesis of rosmanol and its derivatives. Easy access to abietatriene diterpenes isolated from the genus Salvia with biological activities.迷迭香酚及其衍生物的半合成。简便获取从具有生物活性的鼠尾草属植物中分离得到的枞三烯二萜类化合物。
J Nat Prod. 2002 Jul;65(7):986-9. doi: 10.1021/np010565o.