Gheorghe Dan Cristian, Niculescu Adelina-Gabriela, Bîrcă Alexandra Cătălina, Grumezescu Alexandru Mihai
"Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
"M.S. Curie" Clinical Emergency Hospital for Children, 077120 Bucharest, Romania.
Pharmaceutics. 2021 May 27;13(6):803. doi: 10.3390/pharmaceutics13060803.
Thousands of microorganisms coexist within the human microbiota. However, certain conditions can predispose the organism to the overgrowth of specific pathogens that further lead to opportunistic infections. One of the most common such imbalances in the normal oral flora is the excessive growth of spp., which produces oral candidiasis. In immunocompromised individuals, this fungal infection can reach the systemic level and become life-threatening. Hence, prompt and efficient treatment must be administered. Traditional antifungal agents, such as polyenes, azoles, and echinocandins, may often result in severe adverse effects, regardless of the administration form. Therefore, novel treatments have to be developed and implemented in clinical practice. In this regard, the present paper focuses on the newest therapeutic options against oral infections, reviewing compounds and biomaterials with inherent antifungal properties, improved materials for dental prostheses and denture adhesives, drug delivery systems, and combined approaches towards developing the optimum treatment.
数以千计的微生物共存于人类微生物群中。然而，某些情况可能使机体易患特定病原体的过度生长，进而导致机会性感染。正常口腔菌群中最常见的此类失衡之一是 spp. 的过度生长，它会引发口腔念珠菌病。在免疫功能低下的个体中，这种真菌感染可达到全身水平并危及生命。因此，必须进行迅速有效的治疗。传统抗真菌药物，如多烯类、唑类和棘白菌素类，无论给药形式如何，往往都会导致严重的不良反应。因此，必须开发新的治疗方法并在临床实践中应用。在这方面，本文重点关注针对口腔 感染的最新治疗选择，综述具有固有抗真菌特性的化合物和生物材料、用于假牙和假牙粘合剂的改良材料、药物递送系统以及开发最佳治疗方法的联合方法。
