Choe Jung Wan, Hyun Jong Jin, Kim Bongseong, Han Kyung-Do
Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, Korea.
Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
J Clin Med. 2021 May 29;10(11):2401. doi: 10.3390/jcm10112401.
Hepatitis B virus (HBV) infection and metabolic syndrome (MS) are known independent risk factors for hepatocellular carcinoma (HCC) and other extrahepatic organ malignancies. The purpose of this study was to investigate whether MS and HBV have synergistic effects on cancers and to examine whether increasing the number of MS components could lead to higher risk of cancer development.
We evaluated data from 1,504,880 HBV-infected adults who underwent a regular HCC screening program provided by the Korean National Health Insurance Service between 2009 and 2016.
The prevalence of MS in Korean HBV patients was 38.7% (582,449/1,504,880). Among individuals with HBV infection, the presence of MS was associated with an increased risk for the majority of malignancies except for HCC (HR = 0.862, -value < 0.05). The presence of a higher number of MS components was associated with a significantly increased risk of developing cancers in most organs; only HCC was negatively associated with an increasing number of MS components ( < 0.01).
Our data show that the presence of MS increases the risk for most malignancies, excluding HCC. Moreover, we found that as the number of MS components increased, the risk for most cancers also increased; this trend was reversed in HCC.
乙型肝炎病毒（HBV）感染和代谢综合征（MS）是已知的肝细胞癌（HCC）和其他肝外器官恶性肿瘤的独立危险因素。本研究的目的是调查MS和HBV是否对癌症具有协同作用，并检查MS组分数量的增加是否会导致癌症发生风险升高。
我们评估了2009年至2016年间接受韩国国民健康保险服务提供的常规HCC筛查计划的1,504,880名HBV感染成年人的数据。
韩国HBV患者中MS的患病率为38.7%（582,449/1,504,880）。在HBV感染个体中，MS的存在与除HCC外的大多数恶性肿瘤风险增加相关（HR = 0.862，P值<0.05）。MS组分数量较多与大多数器官发生癌症的风险显著增加相关；只有HCC与MS组分数量增加呈负相关（P<0.01）。
我们的数据表明，MS的存在会增加大多数恶性肿瘤的风险，但不包括HCC。此外，我们发现随着MS组分数量的增加，大多数癌症的风险也增加；这种趋势在HCC中相反。
