Wöhr Markus, Kisko Theresa M, Schwarting Rainer K W
Social and Affective Neuroscience Research Group, Laboratory of Biological Psychology, Research Unit Brain and Cognition, Faculty of Psychology and Educational Sciences, KU Leuven, B-3000 Leuven, Belgium.
Leuven Brain Institute, KU Leuven, B-3000 Leuven, Belgium.
Brain Sci. 2021 May 29;11(6):724. doi: 10.3390/brainsci11060724.
The top-ranked cross-disorder risk gene is strongly associated with multiple neuropsychiatric dysfunctions. In a recent series of studies, we applied a genomically informed approach and contributed extensively to the behavioral characterization of a genetic rat model haploinsufficient for the cross-disorder risk gene Because deficits in processing social signals are associated with reduced social functioning as commonly seen in neuropsychiatric disorders, we focused on socio-affective communication through 22-kHz and 50-kHz ultrasonic vocalizations (USV). Specifically, we applied a reciprocal approach for studying socio-affective communication in sender and receiver by including rough-and-tumble play and playback of 22-kHz and 50-kHz USV. Here, we review the findings obtained in this recent series of studies and link them to the key features of 50-kHz USV emission during rough-and-tumble play and social approach behavior evoked by playback of 22-kHz and 50-kHz USV. We conclude that haploinsufficiency in rats leads to robust deficits in socio-affective communication through 22-kHz and 50-kHz USV and associated alterations in social behavior, such as rough-and-tumble play behavior.
排名第一的跨疾病风险基因与多种神经精神功能障碍密切相关。在最近的一系列研究中，我们采用了基因组信息方法，对一种跨疾病风险基因单倍剂量不足的遗传大鼠模型的行为特征做出了广泛贡献。由于处理社交信号的缺陷与神经精神疾病中常见的社交功能降低有关，我们通过22千赫和50千赫的超声波发声（USV）来关注社会情感交流。具体而言，我们采用了一种相互的方法，通过纳入混战游戏以及22千赫和50千赫USV的回放来研究发送者和接收者的社会情感交流。在此，我们回顾了最近这一系列研究中获得的发现，并将它们与混战游戏期间50千赫USV发射的关键特征以及22千赫和50千赫USV回放引发的社会接近行为联系起来。我们得出结论，大鼠的单倍剂量不足会导致通过22千赫和50千赫USV进行的社会情感交流出现严重缺陷，并导致社交行为发生相关改变，例如混战游戏行为。
