College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
Department of Entomology, University of California, Davis, CA 95616, USA.
Nutrients. 2021 May 31;13(6):1881. doi: 10.3390/nu13061881.
The incidence of metabolic and chronic diseases including cancer, obesity, inflammation-related diseases sharply increased in the 21st century. Major underlying causes for these diseases are inflammation and oxidative stress. Accordingly, natural products and their bioactive components are obvious therapeutic agents for these diseases, given their antioxidant and anti-inflammatory properties. Research in this area has been significantly expanded to include chemical identification of these compounds using advanced analytical techniques, determining their mechanism of action, food fortification and supplement development, and enhancing their bioavailability and bioactivity using nanotechnology. These timely topics were discussed at the 20th Frontier Scientists Workshop sponsored by the Korean Academy of Science and Technology, held at the University of Hawaii at Manoa on 23 November 2019. Scientists from South Korea and the U.S. shared their recent research under the overarching theme of Bioactive Compounds, Nanoparticles, and Disease Prevention. This review summarizes presentations at the workshop to provide current knowledge of the role of natural products in the prevention and treatment of metabolic diseases.
21 世纪，包括癌症、肥胖、炎症相关疾病在内的代谢和慢性疾病的发病率急剧上升。这些疾病的主要潜在原因是炎症和氧化应激。因此，鉴于天然产物及其生物活性成分具有抗氧化和抗炎特性，它们显然是这些疾病的治疗药物。该领域的研究已大大扩展，包括使用先进的分析技术对这些化合物进行化学鉴定、确定其作用机制、进行食品强化和补充剂开发，以及使用纳米技术提高其生物利用度和生物活性。这些及时的主题在由韩国科学技术院主办的第 20 届前沿科学家研讨会上进行了讨论，该研讨会于 2019 年 11 月 23 日在夏威夷马诺阿的夏威夷大学举行。来自韩国和美国的科学家在“生物活性化合物、纳米粒子和疾病预防”的总主题下分享了他们最近的研究成果。本综述总结了研讨会的演讲内容，以提供天然产物在预防和治疗代谢性疾病中的作用的最新知识。
Zotero 插件