Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Advanced Materials and Healthcare Technologies, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Molecules. 2021 May 31;26(11):3302. doi: 10.3390/molecules26113302.
Droplet microfluidics can produce highly tailored microparticles whilst retaining monodispersity. However, these systems often require lengthy optimisation, commonly based on a trial-and-error approach, particularly when using bio-instructive, polymeric surfactants. Here, micropipette manipulation methods were used to optimise the concentration of bespoke polymeric surfactants to produce biodegradable (poly(d,l-lactic acid) (PDLLA)) microparticles with unique, bio-instructive surface chemistries. The effect of these three-dimensional surfactants on the interfacial tension of the system was analysed. It was determined that to provide adequate stabilisation, a low level (0.1% (/)) of poly(vinyl acetate-co-alcohol) (PVA) was required. Optimisation of the PVA concentration was informed by micropipette manipulation. As a result, successful, monodisperse particles were produced that maintained the desired bio-instructive surface chemistry.
液滴微流控技术可以在保持单分散性的同时，生产出高度定制化的微颗粒。然而，这些系统通常需要长时间的优化，通常基于试错法，特别是在使用生物指令性、聚合物表面活性剂时。在这里，使用微管操作方法来优化定制聚合物表面活性剂的浓度，以生产具有独特生物指令性表面化学的可生物降解（聚（DL-乳酸）（PDLLA））微颗粒。分析了这些三维表面活性剂对体系界面张力的影响。结果表明，为了提供充分的稳定性，需要低浓度（0.1%（/））的聚醋酸乙烯酯-醇共聚物（PVA）。通过微管操作优化了 PVA 浓度。结果，成功生产出了具有所需生物指令性表面化学的单分散性颗粒。
