Department of Chemical Engineering, University of Pittsburgh, 3700 O'Hara Street, 940 Benedum Hall, Pittsburgh, Pennsylvania 15261, United States.
Department of Dermatology, University of Pittsburgh School of Medicine, 200 Lothrop Street, W1150 Biomedical Science Tower, Pittsburgh, Pennsylvania 15213, United States.
ACS Biomater Sci Eng. 2022 Jul 11;8(7):2864-2877. doi: 10.1021/acsbiomaterials.2c00066. Epub 2022 Jun 8.
Particles synthesized from biodegradable polymers hold great potential as controlled drug delivery systems. Continuous flow platforms based on microfluidics offer attractive advantages over conventional batch-emulsification techniques for the scalable fabrication of drug-loaded particles with controlled physicochemical properties. However, widespread utilization of microfluidic technologies for the manufacturing of drug-loaded particles has been hindered largely by the lack of practical guidelines toward cost-effective development and reliable operation of microfluidic systems. Here, we present a framework for rational design and construction of microfluidic systems using commercially available components for high-throughput production of uniform biodegradable particles encapsulating drugs. We also demonstrate successful implementation of this framework to devise a robust microfluidic system that is capable of producing drug-carrying particles with desired characteristics. The guidelines provided in this study will likely help broaden the applicability of microfluidic technologies for the synthesis of high-quality, drug-loaded biodegradable particles.
由可生物降解聚合物合成的颗粒作为控制药物输送系统具有巨大的潜力。基于微流控技术的连续流平台在可扩展制造具有控制物理化学性质的载药颗粒方面，相较于传统的批量乳化技术具有很大的优势。然而，微流控技术在载药颗粒制造方面的广泛应用在很大程度上受到缺乏经济高效的微流控系统开发和可靠运行的实际指导方针的阻碍。在这里，我们提出了一个使用商业上可获得的组件进行合理设计和构建微流控系统的框架，用于高通量生产包封药物的均匀可生物降解颗粒。我们还展示了如何成功实施该框架来设计一种稳健的微流控系统，该系统能够生产具有所需特性的载药颗粒。本研究中提供的指南可能有助于拓宽微流控技术在高质量载药可生物降解颗粒合成方面的适用性。
