Grimm U, Steinhauser I, Wulff K, Knapp A, Zschiesche M
Institut für Medizinische Genetik, Bereiches Medizin, Ernst-Moritz-Arndt-Universität Greifswald, DDR.
Z Urol Nephrol. 1988 May;81(5):299-303.
In 90 patients with calcium oxalate urolithiasis an oral tryptophan-loading test with 5 g L-tryptophan was performed and the 24-hour urinary excretion of xanthurenic acid and kynurenine was measured. In 10 cases pathological deviations and an excretion pattern of tryptophan metabolites via kynurenine similar as in the hereditary vitamin-B6-dependent xanthurenic aciduria in homozygous or heterozygous from were found. Correlations between the oxalate excretion and the tryptophan metabolism do not exist. A 2-year therapy with 60 mg vitamin B6 was favourable in patients with an excretion of more than 300 mumol XA after a tryptophan load.
对90例草酸钙尿路结石患者进行了口服5克L-色氨酸的色氨酸负荷试验，并测定了24小时尿中黄尿酸和犬尿氨酸的排泄量。在10例患者中发现了病理偏差，其色氨酸代谢产物经犬尿氨酸的排泄模式与纯合子或杂合子遗传性维生素B6依赖型黄尿酸尿症相似。草酸排泄与色氨酸代谢之间不存在相关性。对于色氨酸负荷后黄尿酸排泄量超过300微摩尔的患者，采用60毫克维生素B6进行为期2年的治疗效果良好。
