Skorupska Anna, Lenda Rafał, Ożyhar Andrzej, Bystranowska Dominika
Department of Biochemistry, Molecular Biology and Biotechnology, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.
Int J Mol Sci. 2021 May 26;22(11):5687. doi: 10.3390/ijms22115687.
Nucb2 is a multifunctional protein associated with a variety of biological processes. Multiple studies have revealed that Nucb2, and its derivative nesfatin-1, are involved in carcinogenesis. Interestingly, the role of Nucb2/nesfatin-1 in tumorigenesis seems to be dual-both pro-metastatic and anti-metastatic. The implication of Nucb2/nesfatin-1 in carcinogenesis seems to be tissue dependent. Herein, we review the role of Nucb2/nesfatin-1 in both carcinogenesis and the apoptosis process, and we also highlight the multifaceted nature of Nucb2/nesfatin-1.
Nucb2是一种与多种生物学过程相关的多功能蛋白质。多项研究表明，Nucb2及其衍生物nesfatin-1参与了癌症的发生发展。有趣的是，Nucb2/nesfatin-1在肿瘤发生中的作用似乎具有双重性——既促进转移又抑制转移。Nucb2/nesfatin-1在癌症发生中的影响似乎取决于组织类型。在此，我们综述了Nucb2/nesfatin-1在癌症发生和凋亡过程中的作用，同时也强调了Nucb2/nesfatin-1的多面性。
