Bracco L, Antuono P, Amaducci L
Acta Neurol Scand. 1979 Aug;60(2):112-24. doi: 10.1111/j.1600-0404.1979.tb02958.x.
An epidemiological survey of amyotrophic lateral sclerosis (ALS) based on 83 patients living in the province of Florence (central Italy) showed an incidence of 0.714 X 100,000 inhabitants and a prevalence of 2.142 X 100,000 inhabitants. The disease was found to be more prevalent in males (sex ratio 1.3--1). Average age of onset was 59 years (57 +/- 4 for males and 61.6 +/- 3 for females). No particular geographical distribution was noted. 59 % of the patients presented the conventional amyotrophic form, while 10 % and 30 % were those with the bulbar and polyneuritic type, respectively. A survey of the social and economic status showed ALS to be more frequent in manual workers (P less than 0.001). Among all patients 31 % presented evidence of trauma; however only in 15 % of them could the trauma be chronically and topographically related to the onset of ALS. The presence of other diseases associated with ALS was examined but the combination found may be only casual.
一项针对居住在佛罗伦萨省（意大利中部）的83例肌萎缩侧索硬化症（ALS）患者的流行病学调查显示，发病率为每10万居民中有0.714例，患病率为每10万居民中有2.142例。该疾病在男性中更为普遍（性别比为1.3:1）。平均发病年龄为59岁（男性为57±4岁，女性为61.6±3岁）。未发现特定的地理分布。59%的患者表现为传统的肌萎缩形式，而10%和30%的患者分别为延髓型和多神经炎型。一项关于社会和经济状况的调查显示，体力劳动者中ALS更为常见（P<0.001）。在所有患者中，31%有创伤证据；然而，其中只有15%的创伤在时间和部位上与ALS的发病有长期关联。对与ALS相关的其他疾病的存在情况进行了检查，但所发现的组合可能只是偶然的。
