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The long-term effect of clobazam as adjunctive therapy in epilepsy.

作者信息

Scott D F, Moffett A

机构信息

Department of Clinical Neurophysiology, London Hospital, England.

出版信息

Acta Neurol Scand. 1988 Jun;77(6):498-502. doi: 10.1111/j.1600-0404.1988.tb05947.x.

DOI:10.1111/j.1600-0404.1988.tb05947.x
PMID:3407388
Abstract

Thirty drug-resistant epilepsy patients were given 20-30 mg of clobazam in addition to their other anticonvulsants and followed up for 2-3 years in an open-ended study. Fit frequency was markedly reduced in 43% of patients, few side effects occurred and psychological parameters including the Crown-Crisp questionnaire, showed improvement. It therefore seems that clobazam is a useful additional drug added to conventional anticonvulsant regimes.

摘要

相似文献

1
The long-term effect of clobazam as adjunctive therapy in epilepsy.
Acta Neurol Scand. 1988 Jun;77(6):498-502. doi: 10.1111/j.1600-0404.1988.tb05947.x.
2
On the anticonvulsant and psychotropic properties of clobazam--a preliminary study.氯巴占的抗惊厥和精神药理特性——一项初步研究
Epilepsia. 1986;27 Suppl 1:S42-4. doi: 10.1111/j.1528-1157.1986.tb05732.x.
3
Clobazam for intractable pediatric epilepsy.氯巴占用于治疗儿童难治性癫痫。
J Child Neurol. 1995 May;10(3):205-8. doi: 10.1177/088307389501000306.
4
Clinical experience with clobazam: a new 1,5 benzodiazepine in the treatment of refractory epilepsy.氯巴占的临床经验:一种用于治疗难治性癫痫的新型1,5-苯二氮䓬类药物。
Clin Exp Neurol. 1985;21:177-82.
5
Antiepileptic effects of clobazam in children.氯巴占对儿童的抗癫痫作用。
Brain Dev. 1982;4(1):57-62. doi: 10.1016/s0387-7604(82)80102-2.
6
Clobazam as adjunctive treatment in refractory epilepsy.氯巴占作为难治性癫痫的辅助治疗药物。
Br Med J (Clin Res Ed). 1983 Apr 16;286(6373):1246-7. doi: 10.1136/bmj.286.6373.1246.
7
Current status of the 1,4- and 1,5-benzodiazepines in the treatment of epilepsy: the place of clobazam.1,4-和1,5-苯二氮䓬类药物在癫痫治疗中的现状:氯巴占的地位
Epilepsia. 1986;27 Suppl 1:S27-41. doi: 10.1111/j.1528-1157.1986.tb05730.x.
8
Development of tolerance to anticonvulsant effect of clobazam.对氯巴占抗惊厥作用耐受性的发展
J Neurol Neurosurg Psychiatry. 1985 Mar;48(3):284-5. doi: 10.1136/jnnp.48.3.284.
9
Open study of clobazam in refractory epilepsy.氯巴占治疗难治性癫痫的开放性研究。
Pediatr Neurol. 1993 Nov-Dec;9(6):465-9. doi: 10.1016/0887-8994(93)90026-9.
10
Clobazam in the treatment of epilepsy: prospective follow-up to 8 years.氯巴占治疗癫痫:8年前瞻性随访
J R Soc Med. 1993 Jul;86(7):378-80.

引用本文的文献

1
Clobazam: A Safe, Efficacious, and Newly Rediscovered Therapeutic for Epilepsy.氯巴占:一种安全、有效且新发现的癫痫治疗药物。
CNS Neurosci Ther. 2015 Jul;21(7):543-8. doi: 10.1111/cns.12399. Epub 2015 Apr 28.
2
Clobazam.氯巴占
Neurotherapeutics. 2007 Jan;4(1):138-44. doi: 10.1016/j.nurt.2006.11.002.
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Intermittent clobazam therapy in febrile seizures.氯巴占间歇疗法用于热性惊厥
Indian J Pediatr. 2005 Jan;72(1):31-3. doi: 10.1007/BF02760577.
4
Effects of clobazam and clonazepam on saccadic eye movements and other parameters of psychomotor performance.氯巴占和氯硝西泮对眼球跳动及其他精神运动性能参数的影响。
Eur J Clin Pharmacol. 1989;37(4):365-9. doi: 10.1007/BF00558501.