Kato T, Katagiri T, Hirano A, Sasaki H, Arai S
Third Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Acta Neuropathol. 1988;76(2):208-11. doi: 10.1007/BF00688105.
A sporadic case of lower motor neuron disease with Lewy body-like inclusions is presented. A woman of 69, 6 months before death, had a history of muscle weakness and atrophy of the four extremities. Neuropathological examination revealed neuronal loss and associated gliosis in the anterior horns of the whole spinal cord. The cytoplasm of some of the remaining neurons contained Lewy body-like inclusions. Bunina bodies, or both. Spheroids and cord-like thickenings of cell processes were also observed in the anterior horns. A few neurons showed argentophilia of the cytoplasm. No tract degeneration was detectable in the white matter of the spinal cord. The present case and two reported similar cases may constitute a new subgroup of motor neuron disease.
本文报告一例散发性下运动神经元病伴路易小体样包涵体。一名69岁女性，在死亡前6个月，有四肢肌肉无力和萎缩病史。神经病理学检查显示整个脊髓前角神经元丢失及相关胶质细胞增生。部分残留神经元的细胞质中含有路易小体样包涵体、布尼亚小体或两者皆有。在前角还观察到细胞突起的球形和索状增厚。少数神经元显示细胞质嗜银性。脊髓白质未检测到束状变性。本病例及另外两例报告的类似病例可能构成运动神经元病的一个新亚组。
