Werka T, Gradowska M, Danielsson I
Acta Neurobiol Exp (Wars). 1988;48(1):9-20.
Acquistion and retention of the two-way avoidance was studied in 32 male Moll-Wistar rats, divided into four groups. The first two received electrolytic dorsal hippocampal afferent injuries and were injected either with GM,-ganglioside or buffer. Two remaining groups were sham-operated and injected similarly with either GM, or buffer. The acquistion and retention of avoidance was better in lesioned than is sham-operated groups. Short avoidance latencies, small number of trials to the first avoidance response, and high intertrial responses frequency were also observed in those groups. Ganglioside treatment tended to elihance all behavioral effects of lesions, contrary to its opposite effects in sham-operated group. The results suggest that the GM, ganglioside administration in lesioned rats decreases pain reactivity and/or unconditioned stimulus signaling properties, since the longest initial shock duration was observed in operated, GM, injected group.
在32只雄性莫尔-威斯塔大鼠中研究了双向回避反应的获得与保持，这些大鼠被分为四组。前两组接受了电解性海马背侧传入损伤，并分别注射了GM₁神经节苷脂或缓冲液。其余两组进行假手术，并同样注射GM₁或缓冲液。损伤组的回避反应获得与保持情况比假手术组更好。在这些组中还观察到回避潜伏期短、首次回避反应的试验次数少以及试验间反应频率高。与假手术组中其相反作用相反，神经节苷脂治疗倾向于增强损伤的所有行为效应。结果表明，在损伤大鼠中给予GM₁神经节苷脂可降低疼痛反应性和/或非条件刺激信号特性，因为在手术并注射GM₁的组中观察到初始电击持续时间最长。
