SARS-CoV-2 感染的实体器官移植受者。
The solid organ transplant recipient with SARS-CoV-2 infection.
机构信息
Department of Medicine, Division of Infectious Disease, Columbia University College of Physicians & Surgeons, New York, New York, USA.
出版信息
Curr Opin Organ Transplant. 2021 Aug 1;26(4):412-418. doi: 10.1097/MOT.0000000000000888.
PURPOSE OF REVIEW
The COVID-19 pandemic is a major challenge to global health, particularly among vulnerable populations. Here, we describe the emerging epidemiology and relevant data on treatment options for COVID-19. We discuss the implications of current knowledge for solid organ transplant (SOT) recipients.
RECENT FINDINGS
Risk factors and outcomes of COVID-19 among SOT recipients remain uncertain, but recent data suggest similar outcomes to the general population. Case reports of donor-derived SARS-CoV-2 infection are emerging. Few studies on treatment of COVID-19 among SOT recipients are available, and therefore, general recommendations are similar to the general population. Vaccine efficacy in the SOT population is uncertain.
SUMMARY
COVID-19 remains a significant threat to SOT recipients and studies on treatment and prevention specific to this population are urgently needed. Although vaccines represent the greatest hope to control this pandemic, their efficacy in this immunocompromised population is uncertain.
目的综述
COVID-19 大流行是对全球健康的重大挑战，尤其是对弱势群体而言。在这里，我们描述了 COVID-19 的新兴流行病学和相关治疗选择数据。我们讨论了当前知识对实体器官移植（SOT）受者的影响。
最近的发现
SOT 受者 COVID-19 的危险因素和结局仍不确定，但最近的数据表明与普通人群相似的结局。供体来源 SARS-CoV-2 感染的病例报告正在出现。关于 SOT 受者 COVID-19 治疗的研究很少，因此，一般建议与普通人群相似。SOT 人群中疫苗的有效性不确定。
总结
COVID-19 对 SOT 受者仍然是一个重大威胁，迫切需要针对该人群的治疗和预防研究。尽管疫苗是控制这一大流行的最大希望，但它们在这种免疫功能低下人群中的有效性尚不确定。
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