Eye Center, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
First People's Hospital of Wuyi County, Hangzhou, China.
Sci Rep. 2021 Jun 1;11(1):11517. doi: 10.1038/s41598-021-91110-9.
This study aims to investigate the reliability and efficacy of maximum fluorescein tear break-up time (FTBUTmax) in diagnosing dry eye disease (DED). 147 participants were enrolled in this study. Ocular symptoms were assessed by Ocular Surface Disease Index (OSDI). The fluorescein tear break-up time (FTBUT) examination, corneal fluorescein staining (CFS), and Schirmer I test were performed on both eyes. Each participant underwent 3 consecutive FTBUT tests, and five types of FTBUT values including FTBUTmax, the minimum FTBUT (FTBUTmin), the first FTBUT (FTBUT1), the average of three FTBUTs (FTBUT123) and the average of the first and second FTBUT (FTBUT12) were recorded. FTBUTmax was larger than the other FTBUT values, but no differences were found among the values of FTBUT1, FTBUT123, FTBUT12 and FTBUTmin. In the ROC analysis, FTBUTmax had the largest or the second largest area under the ROC (AUROC) in all three DED diagnostic criteria, while FTBUTmin had the least AUROC of them. ROC efficacy of FTBUTmax was significantly higher than that of FTBUT123, FTBUT12, FTBUT1 and FTBUTmin in the OSDI criteria and higher than that of FTBUT1 and FTBUTmin in Schirmer I test and CFS tests. FTBUTmax has a close correlation with OSDI, Schirmer I test and CFS, and is an effective tool for the DED diagnosis.
本研究旨在探讨最大泪膜破裂时间（FTBUTmax）在诊断干眼病（DED）中的可靠性和有效性。本研究共纳入 147 名参与者。眼表疾病指数（OSDI）评估眼部症状。对双眼进行荧光素泪膜破裂时间（FTBUT）检查、角膜荧光素染色（CFS）和 Schirmer I 试验。每位参与者接受 3 次连续 FTBUT 测试，记录 5 种 FTBUT 值，包括 FTBUTmax、最小 FTBUT（FTBUTmin）、第一 FTBUT（FTBUT1）、三个 FTBUT 的平均值（FTBUT123）和第一个和第二个 FTBUT 的平均值（FTBUT12）。FTBUTmax 大于其他 FTBUT 值，但 FTBUT1、FTBUT123、FTBUT12 和 FTBUTmin 值之间无差异。在 ROC 分析中，FTBUTmax 在所有 3 种 DED 诊断标准中均具有最大或第二大的 ROC 曲线下面积（AUROC），而 FTBUTmin 的 AUROC 最小。在 OSDI 标准中，FTBUTmax 的 ROC 效能明显高于 FTBUT123、FTBUT12、FTBUT1 和 FTBUTmin，高于 Schirmer I 试验和 CFS 试验中的 FTBUT1 和 FTBUTmin。FTBUTmax 与 OSDI、Schirmer I 试验和 CFS 密切相关，是 DED 诊断的有效工具。
